Actively Recruiting

Phase Not Applicable
Age: 25Years - 48Years
FEMALE
ID07526311

Bilateral Uterine Artery Ligation Versus Pericervical Mechanical Tourniquet Application in Reducing Intraoperative Blood Loss During Transabdominal Myomectomy

Led by Cairo University · Updated on 2026-04-13

40

Participants Needed

1

Research Sites

4 weeks

Total Duration

On this page

Sponsors

C

Cairo University

Lead Sponsor

K

Kafrelsheikh University

Collaborating Sponsor

AI-Summary

What this Trial Is About

This research aims to compare two surgical techniques to reduce blood loss during transabdominal myomectomy in women with symptomatic uterine fibroids. The study evaluates whether bilateral uterine artery ligation decreases intraoperative bleeding more effectively than the pericervical mechanical tourniquet, while monitoring for any increase in operative complications. The trial involves women scheduled for elective transabdominal myomectomy who will be randomly assigned to one of these two vascular control methods. Participants will undergo myomectomy using either bilateral uterine artery ligation or pericervical mechanical tourniquet application. In the ligation group, uterine arteries near the internal cervical os are tied with absorbable sutures before removing fibroids. In the tourniquet group, a sterile Foley catheter is tied around the cervico-isthmic region to compress vessels temporarily during surgery. Both procedures are performed by the same surgical team following standardized techniques. During surgery, blood loss is measured from surgical swabs, suctioned blood, and postoperative drainage until the second day after surgery. Researchers will assess the need for blood transfusions up to three days post-operation. Safety and recovery outcomes will also be monitored to determine which method better controls bleeding while maintaining surgical safety. Participation includes follow-up until hospital discharge and close observation of operative effects.

CONDITIONS

Brief Title

Reducing Blood Loss During Myomectomy:Uterine Artery Ligation Vs Pericervical Tourniquet

Who Can Participate

Age: 25Years - 48Years
FEMALE

Eligibility Criteria

Eligible

You may qualify if you...

  • Female participants aged 25 to 48 years
  • Body mass index less than 35 kg/m²
  • Symptomatic uterine myomas requiring surgical treatment
  • Intramural myomas classified as FIGO types 3 to 6
  • Diagnosis confirmed by transvaginal ultrasound and/or magnetic resonance imaging
  • Maximum diameter of the largest myoma 20 cm or less
  • Scheduled for elective transabdominal myomectomy
  • Able and willing to provide written informed consent
Not Eligible

You will not qualify if you...

  • Submucosal, intracavitary, pedunculated subserosal, cervical, or adnexal myomas
  • FIGO types 0, 1, 2, 7, or 8 myomas
  • History of pelvic inflammatory disease or peritonitis
  • Previous abdominal or pelvic surgery for non-obstetric causes
  • Previous uterine surgery
  • Use of hormonal therapy within the previous 3 months
  • Known bleeding disorder
  • Use of anticoagulant or antiplatelet therapy
  • Preoperative hemoglobin less than 10 g/dL
  • Body mass index 35 kg/m² or greater
  • Intraoperative conversion from myomectomy to hysterectomy

AI-Screening

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Surgery and Immediate Post-operative Care

Duration - Single day for surgery plus 2 days of post-operative monitoring

Participants undergo transabdominal myomectomy with either bilateral uterine artery ligation or pericervical mechanical tourniquet applied before myoma enucleation to reduce intraoperative blood loss, followed by uterine repair and hemostasis.

1 surgical visit and daily post-operative assessments for 2 days

Post-operative Follow-up

Duration - Up to 3 days after surgery

Participants are monitored for recovery and any complications including assessment of blood loss and need for blood transfusion until hospital discharge, typically within 3 days after surgery.

Daily visits until discharge

Trial Site Locations

Total: 1 location

1

Cairo University

Cairo, Al-Manial, Egypt, 11956

Actively Recruiting

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Research Team

M

Maged Elmohamady Rashedy, MD

How is the study designed?

Study Type

INTERVENTIONAL

Masking

DOUBLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

SUPPORTIVE_CARE

Number of Arms

2

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