Study on Lowering Blood Pressure in Adults Aged 50-64 Who Binge Drink Effects of Exercise and Alcohol Abstinence on Blood Vessel and Nerve Function

What this Trial Is About

Researchers are investigating blood pressure, microvascular function, and sympathetic nerve activity in mid-life adults who binge drink compared to those who abstain from alcohol or drink moderately. The study aims to better understand these factors in adults aged 50 to 64 years, including the role of aerobic exercise on these health measures. This research is led by The University of Texas at Arlington and focuses on behavioral changes related to alcohol use and exercise. The study has two phases. In Phase 1, participants blood pressure, microvascular function, and nerve activity are measured at baseline. In Phase 2, only binge drinkers are randomized into two groups one group undergoes an 8-week supervised high-intensity interval training program three times per week while abstaining from alcohol, and the other group abstains from alcohol without exercise. After the intervention, these health measures are reassessed to evaluate changes. Participants attend assessments at the beginning and end of the study, with exercise sessions lasting 40 minutes each during the 8-week intervention. Researchers will monitor changes in blood pressure, microvascular function, sympathetic activity, urine catecholamine levels, and alcohol intake. The study also evaluates the feasibility of the exercise program over approximately three months. Safety and adherence are tracked through consultations and education during abstinence periods.

Reducing Blood Pressure in Mid-life Adult Binge Drinkers