Actively Recruiting
Reducing Breathlessness With Dronabinol in COPD Patients
Led by Vejle Hospital · Updated on 2026-04-17
30
Participants Needed
1
Research Sites
83 weeks
Total Duration
On this page
Sponsors
V
Vejle Hospital
Lead Sponsor
R
Region of Southern Denmark
Collaborating Sponsor
AI-Summary
What this Trial Is About
This clinical trial examines whether Dronabinol, which contains the synthetic psychoactive compound tetrahydrocannabinol (THC), can alleviate severe breathlessness in patients with severe and very severe chronic obstructive pulmonary disease (COPD).
CONDITIONS
Official Title
Reducing Breathlessness With Dronabinol in COPD Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Refractory dyspnea despite optimal treatment
- COPD classified as GOLD stage 3 or 4
- Breathlessness with a modified Medical Research Council (mMRC) score of 3 or higher
- Provided informed written consent
- Age 18 years or older
- Cognitively competent and of legal age
- Understands and speaks Danish
- For fertile women with less than 12 months of amenorrhea: negative pregnancy test before trial entry
- Fertile and sexually active participants must use safe contraception during medication intake and for 4 weeks after, including intrauterine device or hormonal contraception methods (oral pill, implant, patch, ring, or injection)
You will not qualify if you...
- Ongoing infection or exacerbation of COPD within the last 30 days
- Regular treatment with THC or CBD within the last 30 days
- Life expectancy less than 90 days
- Treatment with medications that strongly inhibit or induce CYP3A4, CYP2C9, or CYP2C19 enzymes
- History or current significant medical or psychiatric disorders that increase risk of adverse events
- Current or past substance abuse deemed too risky by the investigator
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Vejle Hospital - A part of Lillebaelt Hospital
Vejle, Region Syddanmark, Denmark, 7100
Actively Recruiting
Research Team
S
Sofie K Wolsing, MSc, RN
CONTACT
V
Vejle Hospital
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here