Actively Recruiting
DREAMS-OT Trial: Delirium Reduction Through Early Activation in Motivating and Sleep Promoting Routines: A Randomized Controlled Trial of Occupational Therapy for ICU Patients After Coronary Artery Bypass Graft Surgery
Led by National University Hospital, Singapore · Updated on 2026-03-30
300
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
N
National University Hospital, Singapore
Lead Sponsor
N
National University of Singapore
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are evaluating the DREAMS-OT intervention compared to standard care to reduce delirium after Coronary Artery Bypass Graft (CABG) surgery. This randomized controlled trial aims to see if early and intensive occupational therapy can lower the incidence of delirium in patients within 5 days after surgery. The study also assesses the cost effectiveness of the DREAMS-OT approach. Participants are randomly assigned to one of two groups: the DREAMS-OT intervention group or the standard care group. The DREAMS-OT group receives an early and intensive occupational therapy protocol starting within 15 hours after extubation, with therapy sessions three times daily lasting about 20 minutes each or adjusted to one hour per day if three sessions are not feasible. The control group receives the usual occupational therapy care provided in the ICU. During the study, patients are monitored for delirium twice daily from day 1 to day 5 post-surgery. Additional assessments include length of hospital stay, duration of delirium, sleep quality, functional and physical status, cognitive and psychological state at various points before and up to three months after surgery. These evaluations help measure the effects of the therapy on recovery and wellbeing. The study runs until August 2026 and includes adults aged 21 to 99 years undergoing elective CABG surgery.
CONDITIONS
Brief Title
Reducing Delirium After CABG Surgery With Early Activation and Sleep-Promoting Routines
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients deemed medically suitable for elective CABG surgery
- Patients aged 21 years and above
- Patients who are English or Mandarin speaking
- Patients who are able to provide consent
You will not qualify if you...
- Patients who speak other languages due to language requirements of outcome measures
- Patients with premorbid severe hearing impairment, severe cognitive impairment, progressive neurological disorders, or psychological disorders
- Patients with surgical complications causing profuse bleeding, septic shock unresponsive to treatment, or expected mortality within 48 hours
- Pregnant women
- Patients who develop delirium before starting treatment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 5 days post-surgery
Participants receive the DREAMS-OT occupational therapy protocol starting within 15 hours after extubation following coronary artery bypass graft surgery, provided 3 times per day with 20-minute sessions or adjusted intensity if needed.
Daily visits twice per day for up to 5 days
Duration - Up to 3 months post-surgery
Participants are monitored for sleep quality, physical, cognitive, and psychological status up to 3 months after surgery to assess longer-term effects.
Visits at 3 months post-surgery including 3 consecutive days of assessments
Trial Site Locations
Total: 1 location
1
National University Hospital
Singapore, Singapore, 119074
Actively Recruiting
Research Team
M
Megan HL Tan
M
Michell KS Low
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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