Actively Recruiting
Reducing Dropout and Improving Outcomes From PTSD Therapy: When to Switch Therapies or Stay the Course
Led by United States Department of Defense · Updated on 2025-11-14
280
Participants Needed
4
Research Sites
180 weeks
Total Duration
On this page
Sponsors
U
United States Department of Defense
Lead Sponsor
U
University of Minnesota
Collaborating Sponsor
AI-Summary
What this Trial Is About
Investigators' overall objective is to compare methods of identifying individuals who may be experiencing challenges in Cognitive Processing Therapy (CPT) and compare methods of intervening to optimize treatment retention and outcomes. Investigators' specific aims are: 1. to determine whether the use of CPT skills versus collaboratively considering switching to Present Centered Therapy (PCT) is more effective in improving outcomes for individuals experiencing challenges with CPT. Outcomes include post-traumatic stress disorder (PTSD) severity \[primary\], depression, functioning, and treatment retention; 2. to compare two approaches to identifying individuals in CPT in need of additional support during treatment; 3. to study the barriers and facilitators of implementing these intervention strategies. Finally, exploratory aims will examine the stability of differences between treatment conditions, compare combinations of interventions tested, and examine moderators of intervention effects.
CONDITIONS
Official Title
Reducing Dropout and Improving Outcomes From PTSD Therapy: When to Switch Therapies or Stay the Course
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Veterans interested in outpatient VA psychotherapy for PTSD
- Meets DSM-5 criteria for PTSD
- Able to provide informed consent
- Willing to be randomized
- Agree not to receive non-study psychotherapy for PTSD during study treatment (case management, supportive therapy/group, and concurrent substance use treatment allowed)
You will not qualify if you...
- Severe cognitive impairment
- Current suicidal or homicidal intent with a specific plan
- Uncontrolled psychotic or manic symptoms
- Psychiatric medication change in the past month
- Severe substance use disorder as diagnosed by DSM-5
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 4 locations
1
VA Phoenix Health Care System
Phoenix, Arizona, United States, 85012
Actively Recruiting
2
New Orleans VA Medical Center
New Orleans, Louisiana, United States, 70119
Actively Recruiting
3
Ralph H. Johnson VA Health Care System (Charleston VA)
Charleston, South Carolina, United States, 29401
Actively Recruiting
4
VA Houston Healthcare System
Houston, Texas, United States, 77030
Actively Recruiting
Research Team
E
Emily M Hudson, PhD
CONTACT
D
Donald Lemon
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
FACTORIAL
Primary Purpose
TREATMENT
Number of Arms
4
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