Actively Recruiting
Reducing Empiric VAncomycin Use in Pediatric Suspected Sepsis
Led by Children's Hospital of Philadelphia · Updated on 2025-09-19
52500
Participants Needed
4
Research Sites
140 weeks
Total Duration
On this page
Sponsors
C
Children's Hospital of Philadelphia
Lead Sponsor
C
Children's Healthcare of Atlanta
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this quasi-experimental interventional study is to determine the effectiveness of a multifaceted stewardship intervention in reducing overall vancomycin use in five tertiary care Pediatric Intensive Care Units (PICU). There are two groups of subjects in this study: PICU clinicians/sepsis stakeholders and patients admitted to one of the participating PICUs during the study period. The intervention will at a minimum include: * Implementation of a clinical guideline indicating when vancomycin should and should not be used * Unit-level feedback on overall vancomycin use within and across centers * Clinician education.
CONDITIONS
Official Title
Reducing Empiric VAncomycin Use in Pediatric Suspected Sepsis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patient admitted to one of the participating PICUs during the study period
- PICU prescribing clinician or sepsis stakeholder at a participating site when the survey is deployed
- Age 18 years or older (for clinicians/stakeholders)
- Employed by one of the participating sites (for clinicians/stakeholders)
You will not qualify if you...
- Volunteers or other non-employee hospital staff
- Limited English proficiency
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 4 locations
1
Children's Healthcare of Atlanta
Atlanta, Georgia, United States, 30322
Actively Recruiting
2
Johns Hopkins Children's Center
Baltimore, Maryland, United States, 21287
Actively Recruiting
3
St. Louis Children's Hospital
St Louis, Missouri, United States, 63110
Actively Recruiting
4
Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, United States, 19146
Actively Recruiting
Research Team
K
Kathleen Chiotos, MD, MSCE
CONTACT
K
Kai Inoki, MPH
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SINGLE_GROUP
Primary Purpose
OTHER
Number of Arms
2
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