Actively Recruiting
Reducing Gastrointestinal Bleeding With Proton Pump Inhibitor Therapy in Acute Venous Thromboembolism
Led by Ottawa Hospital Research Institute · Updated on 2026-01-22
360
Participants Needed
7
Research Sites
173 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The investigators are studying whether treatment with a proton pump inhibitor called omeprazole reduces gastrointestinal bleeding in older adults taking blood thinners for a blood clot (venous thromboembolism). The purpose of this study, a pilot study or a feasibility study, is to test the study plan and determine whether enough participants will join a larger study and accept the study procedures.
CONDITIONS
Official Title
Reducing Gastrointestinal Bleeding With Proton Pump Inhibitor Therapy in Acute Venous Thromboembolism
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female aged 65 years or older at enrollment
- Newly diagnosed venous thromboembolism including blood clots in arms, legs, lungs, brain, or abdomen
- Planned treatment with blood thinners for 90 days or more
- Ability and willingness to comply with follow-up examinations and study procedures
You will not qualify if you...
- More than 7 days of blood thinner treatment before enrollment
- Currently prescribed proton pump inhibitors for daily use
- Previous history of upper gastrointestinal bleeding
- Need for dual antiplatelet therapy
- Allergies or contraindications to omeprazole or related medications
- Life expectancy less than 3 months
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 7 locations
1
The Ottawa Hospital
Ottawa, Ontario, Canada, K1H 8L6
Actively Recruiting
2
Niagara Health System - St. Catharines Site
St. Catharines, Ontario, Canada, L2S 0A9
Not Yet Recruiting
3
University Health Network - Toronto General
Toronto, Ontario, Canada, M5G 2c4
Actively Recruiting
4
CIUSSS de l'Est-de- l'Île-de-Montréal
Montreal, Quebec, Canada, H1T2M4
Not Yet Recruiting
5
Centre hospitalier de l'Université de Montréal
Montreal, Quebec, Canada, H2X 0A9
Actively Recruiting
6
CHU de Québec-Université Laval; Hôpital Saint-François d'Assise
Québec, Quebec, Canada, G1R2J6
Actively Recruiting
7
Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval
Québec, Quebec, Canada, G1V4G5
Actively Recruiting
Research Team
D
Deborah Siegal, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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