Actively Recruiting

Phase 2
Age: 18Years +
All Genders
NCT05692635

Reducing the Incidence of Symptomatic Brain Metastases With MRI Surveillance

Led by Wake Forest University Health Sciences · Updated on 2026-03-20

60

Participants Needed

1

Research Sites

239 weeks

Total Duration

On this page

Sponsors

W

Wake Forest University Health Sciences

Lead Sponsor

N

National Cancer Institute (NCI)

Collaborating Sponsor

AI-Summary

What this Trial Is About

The purpose of this research is to see if monitoring the brain using magnetic resonance imaging (MRI) after radiation therapy will allow investigators to find cancer that has spread to the brain (brain metastases) before it causes symptoms.

CONDITIONS

Official Title

Reducing the Incidence of Symptomatic Brain Metastases With MRI Surveillance

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Age 63 18 years
  • Diagnosis of non-squamous locally advanced lung cancer stage IIIA, IIIB, or IIIC according to AJCC version 8
  • Histology described as adeno-squamous or not otherwise specified favoring squamous
  • Enrollment before or after start of radiation therapy but first surveillance brain MRI must be at 120 �b1 10 days from first radiation treatment
  • Eastern Cooperative Oncology Group (ECOG) performance status 0 to 3
  • Epidermal growth factor receptor (EGFR) clearance > 30 mL/min/1.73m2
  • Eligibility for brain MRI per Wake Forest MRI safety screening checklist
Not Eligible

You will not qualify if you...

  • Known brain metastases on staging MRI
  • Pregnant or breastfeeding
  • Premenopausal persons of childbearing potential without a negative pregnancy test within 14 days of enrollment
  • Women not meeting the definition of non-childbearing potential without need for pregnancy test
  • Suspected or confirmed pregnancy during study participation must be reported immediately

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

Wake Forest Baptist Comprehensive Cancer Center

Winston-Salem, North Carolina, United States, 27157

Actively Recruiting

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Research Team

S

Study Coordinator

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NA

Model

SINGLE_GROUP

Primary Purpose

DIAGNOSTIC

Number of Arms

1

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