Actively Recruiting
Reducing Mortality in Adults With Advanced HIV Disease (REVIVE)
Led by Population Health Research Institute · Updated on 2025-09-03
8000
Participants Needed
52
Research Sites
316 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
A double blinded, placebo-controlled, multicenter trial to evaluate effectiveness of azithromycin prophylaxis on mortality in advanced HIV.
CONDITIONS
Official Title
Reducing Mortality in Adults With Advanced HIV Disease (REVIVE)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Documented HIV infection
- CD4 count 100 cells/mm3 or less within the past 4 weeks; or documented CD4 nadir 100 cells/mm3 or less with a complete interruption of antiretroviral therapy for 6 months or more; or documented CD4 count 100 cells/mm3 or less if antiretroviral therapy-naive
- Ability to start or restart antiretroviral therapy, or switch to an effective regimen if current therapy is failing, within 4 weeks of enrollment
You will not qualify if you...
- Allergy or hypersensitivity to azithromycin, erythromycin, or any macrolide antibiotics
- Personal or family history of QT prolongation
- Severe illness requiring immediate or ongoing hospitalization as judged by study investigators
- Current off-label use of azithromycin prophylaxis or need for prolonged azithromycin or macrolide therapy longer than 7 days
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 52 locations
1
Centre Intégré de Recherches Biocliniques d'Abidjan (CIRBA)
Abidjan, Côte d’Ivoire
Not Yet Recruiting
2
Centre médical de suivi des donneurs de sang (CMSDS)
Abidjan, Côte d’Ivoire
Not Yet Recruiting
3
Unité de Soins Ambulatoires et de conseils (USAC)
Abidjan, Côte d’Ivoire
Not Yet Recruiting
4
Adama Hospital Medical College
Ādama, Ethiopia
Actively Recruiting
5
Asella Referral and Teaching Hospital
Āsela, Ethiopia
Actively Recruiting
6
Jimma University Hospital
Jimma, Ethiopia
Actively Recruiting
7
Tigray health research institute (THRI)
Mek'ele, Ethiopia
Not Yet Recruiting
8
Komfo Anokye Teaching Hospital
Kumasi, Ghana
Not Yet Recruiting
9
Kumasi South Hospital
Kumasi, Ghana
Actively Recruiting
10
Suntreso Government Hospital
Kumasi, Ghana
Actively Recruiting
11
Lilongwe Medical Relief Fund/UNC Project
Lilongwe, Malawi
Not Yet Recruiting
12
Faculty of Medicine, Eduardo Mondlane University
Maputo, Mozambique
Not Yet Recruiting
13
University of Abuja Teaching Hospital
Abuja, Nigeria
Not Yet Recruiting
14
University of Calabar Teaching Hospital
Calabar, Nigeria
Not Yet Recruiting
15
University of Nigeria Teaching Hospital
Enugu, Nigeria
Actively Recruiting
16
University College Hospital
Ibadan, Nigeria
Actively Recruiting
17
Jos University Teaching Hospital
Jos, Nigeria
Active, Not Recruiting
18
Aminu Kano Teaching Hospital
Kano, Nigeria
Not Yet Recruiting
19
Lagos University Teaching Hospital
Lago, Nigeria
Actively Recruiting
20
Usmanu Danfodiyo University Teaching Hos
Sokoto, Nigeria
Active, Not Recruiting
21
Federal Medical Center
Umuahia, Nigeria
Not Yet Recruiting
22
University of Uyo Teaching Hospital
Uyo, Nigeria
Active, Not Recruiting
23
Niger Delta University Teaching Hospital
Yenagoa, Nigeria
Not Yet Recruiting
24
Centre Hospitalier Universitaire de Kigali (CHUK)
Kigali, Rwanda
Not Yet Recruiting
25
34 Military Hospital
Freetown, Sierra Leone
Actively Recruiting
26
College of Medicine and Allied Health Sciences, University of Sierra Leone
Freetown, Sierra Leone
Actively Recruiting
27
Kenema Regional Hospital
Kenema, Sierra Leone
Actively Recruiting
28
Koidu Government Hospital
Koidu, Sierra Leone
Actively Recruiting
29
Makeni Regional Hospital
Makeni, Sierra Leone
Actively Recruiting
30
Desmond Tutu Health Foundation
Cape Town, South Africa
Not Yet Recruiting
31
Groote Schuur Hospital -New main building, Infectious Disease Clinic G26
Cape Town, South Africa
Not Yet Recruiting
32
New Somerset Hospital
Cape Town, South Africa
Actively Recruiting
33
Ubuntu Clinic, Site B, Khayelitsha, Wellcome Centre
Cape Town, South Africa
Actively Recruiting
34
Africa Health Research Institute (AHRI)- Nkundusi Clinic
Hlabisa, South Africa
Not Yet Recruiting
35
Africa Health Research Institute (AHRI)- Hluhluwe Clinic
Hluhluwe, South Africa
Not Yet Recruiting
36
Wits Health Consortium (Pty) Ltd
Johannesburg, South Africa
Actively Recruiting
37
The Aurum Institute
Klerksdorp, South Africa
Not Yet Recruiting
38
Africa Health Research Institute (AHRI)- KwaMsane Clinic
Mtubatuba, South Africa
Not Yet Recruiting
39
Africa Health Research Institute (AHRI)- Mpukunyoni Clinic
Mtubatuba, South Africa
Not Yet Recruiting
40
Africa Health Research Institute (AHRI)- Mtubatuba Clinic
Mtubatuba, South Africa
Not Yet Recruiting
41
Africa Health Research Institute (AHRI)- Somkhele Clinic
Mtubatuba, South Africa
Not Yet Recruiting
42
Livingstone hospital
Port Elizabeth, South Africa
Actively Recruiting
43
Steve Biko Academic Hospital, University of Pretoria
Pretoria, South Africa
Actively Recruiting
44
Right to Care NPC, Esizayo Division
Randburg, South Africa
Completed
45
The Aurum Institute
Rustenburg, South Africa
Not Yet Recruiting
46
MUJHU
Kampala, Uganda
Actively Recruiting
47
SICRA Kampala
Kampala, Uganda
Actively Recruiting
48
SICRA Lira
Lira, Uganda
Actively Recruiting
49
Mbarara Regional Referral hospital
Mbarara, Uganda
Actively Recruiting
50
The Center for Infectious Disease Research in Zambia (CIDRZ)- George Clinical Research Site
Lusaka, Zambia
Not Yet Recruiting
51
The Center for Infectious Disease Research in Zambia (CIDRZ)- Matero Clinical Research Site
Lusaka, Zambia
Not Yet Recruiting
52
The Center for Infectious Disease Research in Zambia (CIDRZ)-Chawama Clinical Research Site (CRS)
Lusaka, Zambia
Not Yet Recruiting
Research Team
R
REVIVE Study Coordinator
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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