Actively Recruiting
Reducing Neoplasia Recurrence After Endoscopic Resection of Large Colorectal Polyps
Led by Centre hospitalier de l'Université de Montréal (CHUM) · Updated on 2024-11-25
892
Participants Needed
1
Research Sites
193 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Large (≥20mm) colorectal polyps often harbor areas of advanced neoplasia, making them immediate colorectal cancer (CRC) precursors. Such polyps have to be completely removed to prevent CRC and to avoid surgery and/or adjuvant therapy. The laterally spreading lesions (LSLs) are removed via endoscopic mucosal resection (EMR). However, recurrence is common. New techniques for LSL resection (hybrid argon plasma coagulation (h-APC) margin and base ablation) have shown a reduction in recurrence following the interventions. We hypothesize that performing hybrid argon plasma coagulation (h-APC) margin and base ablation during EMR of large (≥20mm) colorectal LSLs will lead to lower rates of lesion recurrence compared to Snare tip soft coagulation (STSC) margin ablation.
CONDITIONS
Official Title
Reducing Neoplasia Recurrence After Endoscopic Resection of Large Colorectal Polyps
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults 18 years old or older
- Undergoing EMR for a large (20mm or larger) colorectal laterally spreading lesion
- Able to provide written and informed consent to participate in the study
You will not qualify if you...
- Having inflammatory bowel disease
- Undergoing non-elective colonoscopy
- Poor general health classified as American Society of Anesthesiologists class greater than III
- Having blood clotting disorders or low platelets (INR greater than 1.5 or platelets below 50 x 10^9/L)
- Presence of pedunculated polyps (Paris class Ip, Isp)
- Visible signs of deep submucosal invasive cancer (JNET 3)
- Biopsy confirmed invasive cancer in the polyp
- Being pregnant
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Centre Hospitalier de l'Université de Montréal
Montreal, Quebec, Canada
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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