Actively Recruiting
Reducing Risk for Infective Endocarditis
Led by Wake Forest University Health Sciences · Updated on 2025-08-22
320
Participants Needed
6
Research Sites
208 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This clinical trial is studying if bacteria found in a participant's bloodstream after brushing their teeth can be prevented with a dental cleaning and more education on how to best brush and care for their teeth. One group of participants will have a dental cleaning and oral health instructions and the other group of participants will not. Researchers will compare the blood test results from the two groups to see if the education made a difference in preventing bacteria and how long it stays in the bloodstream.
CONDITIONS
Official Title
Reducing Risk for Infective Endocarditis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older.
- More than 6 months since last dental hygiene cleaning.
- At least 10 accessible teeth, including implants, with a minimum of 8 natural teeth.
- Able and willing to provide informed consent.
- Willing to follow all study procedures and be available for the study duration.
- Willing to avoid routine professional dental cleanings during the trial.
You will not qualify if you...
- High risk for Infective Endocarditis as defined by 2007/2021 AHA Guidelines, including prosthetic cardiac valves, previous IE, cardiac transplant with valvulopathy, or specific congenital heart diseases.
- Pregnant or planning pregnancy during the study.
- Conditions that may increase risk or prevent study completion, such as hemodialysis dependence, long-term intravascular catheter, active injection drug use, clotting disorders, organ or stem cell transplant, or ongoing hematologic cancer treatment.
- Currently incarcerated.
- Systemic antibiotic use within the past 2 weeks.
- Undergoing or planning orthodontic treatment with fixed appliances during the study.
- Taking or needing antibiotic prophylaxis for dental procedures for other reasons.
- Having three or more teeth with moderate to severe gingival hyperplasia.
- Urgent dental needs requiring definitive care during the study period as judged by the oral examiner.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 6 locations
1
Tufts University School of Dental Medicine and Tufts University Health Sciences Campus
Boston, Massachusetts, United States, 02111
Withdrawn
2
University of Michigan School of Dentistry and Michigan Medicine
Ann Arbor, Michigan, United States, 48109
Actively Recruiting
3
Rutgers School of Dental Medicine
Newark, New Jersey, United States, 07103
Completed
4
New York University
New York, New York, United States, 10010
Not Yet Recruiting
5
University of Rochester Medical Center
Rochester, New York, United States, 14620
Active, Not Recruiting
6
Atrium Health's Carolinas Medical Center
Charlotte, North Carolina, United States, 28203
Actively Recruiting
Research Team
C
Cathy Petersen, RDH
CONTACT
K
Kate Sullivan, MA
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here