Actively Recruiting
Reduction of Blood Recirculation in Veno-Venous ECMO Using Ultrasound Dilution Measurements An Observational Study in Acute Respiratory Distress Syndrome
Led by Charite University, Berlin, Germany · Updated on 2024-12-31
136
Participants Needed
1
Research Sites
310 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research investigates the reduction of blood recirculation in patients with acute respiratory distress syndrome (ARDS) who are receiving veno-venous extracorporeal membrane oxygenation (V-V ECMO) therapy. Blood recirculation in the ECMO circuit, called the recirculation fraction (Rf), does not help oxygenate the patient. The study aims to optimize ECMO blood flow by measuring and reducing this recirculation fraction without compromising systemic oxygen levels. The study is prospective and observational, using an ultrasound dilution technique to measure the recirculation fraction in patients on V-V ECMO. Based on previous data, around 136 patients will be enrolled to find 68 patients with a relevant recirculation fraction to study. The intervention involves adjusting the ECMO blood flow by reducing it according to the measured Rf to improve treatment safety and effectiveness. Participants will be monitored for successful ECMO blood flow reduction within the first week after starting ECMO therapy. Researchers will evaluate if the optimization of blood flow based on Rf measurements can be safely achieved. The total study enrollment is designed to ensure enough patients with significant recirculation are included for meaningful analysis.
CONDITIONS
Official Title
Reduction of Blood Recirculation in Veno-Venous ECMO
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged 18 years or older
- Patients requiring veno-venous ECMO for treatment of refractory hypoxemia in ARDS
You will not qualify if you...
- None explicitly stated
AI-Screening
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Trial Site Locations
Total: 1 location
1
Charité - Universitätsmedizin Berlin, Campus Virchow Klinikum
Berlin, Germany, 13353
Actively Recruiting
Research Team
S
Steffen Weber-Carstens, Prof. Dr. med.
M
Martin Russ, Dr. med.
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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