Actively Recruiting
Reduction of Postoperative Radiotherapy in Head and Neck Squamous Cell Carcinoma
Led by Sun Yat-sen University · Updated on 2026-04-30
50
Participants Needed
1
Research Sites
274 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
To explore the control rate and quality of life of participants with late head and neck squamous cell carcinoma who have obtained postoperative pCR after cervical lymph node surgery with neoadjuvant chemotherapy combined with immunotherapy, and the cervical lymph node removal prophylactic irradiation ENI in the low-risk area.
CONDITIONS
Official Title
Reduction of Postoperative Radiotherapy in Head and Neck Squamous Cell Carcinoma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Preoperative pathologically confirmed initial treatment of head and neck squamous cell carcinoma
- Received neoadjuvant chemotherapy combined with PD-1 monoclonal antibody immunotherapy
- Preoperative clinical stage T3-T4 or N2-N3 (AJCC 8th edition)
- For oral/oropharyngeal cancer, positive lymph nodes in IV/V region by imaging or biopsy before surgery
- HPV/P16-positive oropharyngeal cancer with clinical lymph node invasion, one positive lymph node >3 cm or multiple positive nodes before surgery
- Pathology shows at least one cervical lymph node with complete pathological response (pCR)
- Karnofsky physical status score ≥70 points
- Age between 18 and 70 years
- Laboratory tests within 1 week before enrollment: neutrophils ≥1.5×10^9/L, platelets ≥75×10^9/L
- Voluntary participation and signed informed consent forms
You will not qualify if you...
- Previous head and neck radiation treatment
- Severe complications
- Pregnant or lactating women
- Deemed unsuitable for inclusion by the researchers
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Sun Yat-sen University Cancer Center
Guangzhou, Guangdong, China, China
Actively Recruiting
Research Team
C
Chun-Yan Chen
CONTACT
Y
Ya-Ni Zhang
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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