Actively Recruiting
Refusal of Sentinel Lymph Node Biopsy in Patients With Luminal A Subtype Early Breast Cancer
Led by N.N. Petrov National Medical Research Center of Oncology · Updated on 2026-05-12
100
Participants Needed
1
Research Sites
199 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Sentinel lymph node biopsy (SLNB) is the standard of axillary lymph node surgical staging in patients with early breast cancer. The main goal of the study is to abandon axillary surgery in patients over 59 years old with early, luminal A, clinical lymph node negative breast cancer.
CONDITIONS
Official Title
Refusal of Sentinel Lymph Node Biopsy in Patients With Luminal A Subtype Early Breast Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- HER2-negative breast cancer (ER+/PR+), Ki67 ≤ 30%, Grade 1-2
- Age over 59 years
- Morphologically confirmed breast cancer, stage IA-IIA
- ECOG performance status 0-2
- No contraindications to surgery including anesthetic risk
- Able to provide informed consent
- Patients treated with breast resection with or without sentinel lymph node biopsy
- Axillary lymph nodes negative (N0) by ultrasound and SPECT-CT with 99mTc-Technetril
You will not qualify if you...
- Not meeting inclusion criteria
- Cancer stage T2-4, N1 or M1
- Severe uncontrolled chronic or acute diseases
- Previous or concurrent cancer or history of radiation to chest wall
- Any contraindication to radiation therapy
- Pregnancy
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
N.N. Petrov National Medical Research Center of Oncology
Saint Petersburg, Russian Federation, Russia, 197758
Actively Recruiting
Research Team
P
Petr Krivorotko, Degree
CONTACT
A
Arina Gorina
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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