Study of Fat Tissue Differences in Abdominal and Other Areas in Adults With or Without Type 2 Diabetes and Obesity

What this Trial Is About

Researchers are studying how fat tissue in different parts of the body, especially abdominal fat, relates to the development of diseases like type 2 diabetes and cardiovascular disease. The study aims to understand how abdominal fat causes or contributes to these diseases and how the diseases may affect fat tissue. This observational study involves adults aged 18 to 65, including people with obesity, diabetes, and lean individuals. The study will include 140 participants divided into three groups 40 people with obesity undergoing bariatric surgery, 40 with diabetes also undergoing bariatric surgery, and 60 healthy lean participants undergoing general abdominal surgery. Participants are recruited from hospital patients awaiting surgery and from the general population. This design allows comparison of fat tissue characteristics across these groups. Participants will be assessed over up to 5 years, focusing on immune cell counts, features of fat cells, and blood markers of inflammation. Researchers will collect data during surgery and follow up with participants to monitor changes. The study will provide valuable information on fat tissue and its role in metabolic diseases to improve understanding of these conditions.

Regional Adipose Tissue Characteristics in Type II Diabetes