Actively Recruiting
Regional Adipose Tissue Characteristics in Type II Diabetes
Led by Concordia University, Montreal · Updated on 2024-10-22
140
Participants Needed
1
Research Sites
500 weeks
Total Duration
On this page
Sponsors
C
Concordia University, Montreal
Lead Sponsor
M
McGill University Health Centre/Research Institute of the McGill University Health Centre
Collaborating Sponsor
AI-Summary
What this Trial Is About
Fat tissue in different parts of the body has different characteristics. Several studies have associated abdominal fat to an increased risk for multiple metabolic diseases, such as type 2 diabetes and cardiovascular disease, compared with fat located under the skin at the hips and thighs. However, the investigators do not know how the abdominal fat causes or contributes to the development of these diseases or how the development of these disease may in turn cause or contribute to changes in the fat tissue. The general objective of this study is to understand these mechanisms. To investigate these questions, the study will recruit 140 participants, both men and women aged 18-65 years. The participants will be divided into three groups: 40 people with obesity, 40 with diabetes, and 60 lean individuals. Participants will be recruited from patients at the CIUSSS du Nord-de-l'Île-de Montréal - Hôpital du Sacré-Coeur de Montréal who are awaiting bariatric or general abdominal surgery, as well as from the general population in the Montreal area.
CONDITIONS
Official Title
Regional Adipose Tissue Characteristics in Type II Diabetes
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Men, premenopausal and postmenopausal females between 18-65 years
- Planning to undergo bariatric surgery (for obesity group) or general abdominal surgery lasting less than 1.5 hours (for normal weight group)
- Body mass index (BMI) of 30 kg/m2 or higher for participants with obesity
- Stable body weight for at least two months before the first pre-operative visit
You will not qualify if you...
- Smoking
- Kidney problems indicated by creatinine clearance less than 60 ml/minute
- Uncontrolled hypothyroidism
- Having other diseases besides type 2 diabetes, except controlled hypertension, controlled hypothyroidism, or controlled dyslipidemia
- Taking medications that affect study outcomes, except stable use of metformin, DPP-4 inhibitors, alpha-glucosidase inhibitors, hypotensive drugs, or lipid-lowering drugs for at least 3 months
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Concordia University (School of Health)
Montreal, Quebec, Canada, H4B 1R6
Actively Recruiting
Research Team
S
Sylvia Santosa, R.D., PhD.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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