Actively Recruiting
Regional Anesthesia in Minimally Invasive Lumbar Spine Surgery
Led by John O'Toole · Updated on 2026-02-17
125
Participants Needed
1
Research Sites
273 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Opioid overuse is a widespread public health crisis in the United States with increasing rates of addiction and overdose deaths from prescription opioids. Reducing the need for opiate analgesics in the post-operative setting has become a high priority in minimizing long-term opioid use in surgical patients. This study will serve to demonstrate the efficacy of the addition of regional analgesic techniques in reducing post-operative opioid requirements in patients undergoing common lumbar spinal surgical procedures.
CONDITIONS
Official Title
Regional Anesthesia in Minimally Invasive Lumbar Spine Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 80 years
- Undergoing one of these procedures: 2 or more levels of minimally invasive decompression, 1-3 levels of minimally invasive transforaminal lumbar interbody fusion (with or without additional decompression up to 3 levels), or 1-3 levels of anterior or lateral lumbar interbody fusion with posterior percutaneous instrumentation
- Able and willing to provide informed consent
You will not qualify if you...
- Opioid tolerant before surgery, defined as using more than 30 mg morphine milligram equivalents daily
- Having an implanted pain device such as an intrathecal opioid pump, spinal cord stimulator, or dorsal root ganglion stimulator
- Known allergy to bupivacaine, clonidine, or related local anesthetics
- Surgery planned for reasons other than degenerative spine disease (such as tumor, infection, or trauma)
- Chronic kidney disease stage 3 or higher, or liver failure
- Currently pregnant
- Having disease or mental illness that prevents accurate pain assessment in the perioperative period
- Active Worker's Compensation litigation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Rush University Medical Center
Chicago, Illinois, United States, 60612
Actively Recruiting
Research Team
B
Bart Jacher
CONTACT
M
Morgan Mulcahy
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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