Alterations in nasal microbiota of patients with amyotrophic lateral sclerosis.
Kaixiong Liu, Qifu Guo, Ying Ding...
https://pubmed.ncbi.nlm.nih.gov/37482646Actively Recruiting
All Genders
ID04008329
A Registered Cohort Study on Amyotrophic Lateral Sclerosis
Led by First Affiliated Hospital of Fujian Medical University · Updated on 2021-03-22
2000
Participants Needed
1
Research Sites
1565 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Amyotrophic lateral sclerosis (ALS) is a motor neuron disease that varies widely among patients and currently has no effective treatment. This registered cohort study aims to observe the natural progression of ALS in Chinese patients, identify factors linked to how the disease develops, and explore genetic mutations related to ALS, including searching for new disease-causing genes. The study is sponsored by the First Affiliated Hospital of Fujian Medical University. This observational study does not involve any treatment but focuses on collecting data from patients diagnosed with ALS and related conditions such as progressive muscular atrophy, primary lateral sclerosis, and progressive bulbar palsy. Researchers will monitor participants over time to gather information about the clinical course and genetic background of the disease. Participants will be followed to record key outcomes such as age at death and age at which life-support interventions like endotracheal intubation or tracheotomy are needed. The study includes ongoing observation and data collection to better understand disease progression and risk factors over a period of up to ten years from enrollment.
CONDITIONS
Brief Title
A Registered Cohort Study on Amyotrophic Lateral Sclerosis
Who Can Participate
All Genders
Eligibility Criteria
You may qualify if you...
- Patients diagnosed with amyotrophic lateral sclerosis fulfilling the El Escorial criteria (including definite, probable, and possible cases)
- Patients with progressive muscular atrophy
- Patients with primary lateral sclerosis
- Patients with progressive bulbar palsy
You will not qualify if you...
- History of serious head trauma or neuropsychiatric disease
- Decline to participate
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Long-term Monitoring
Duration - Up to 40 years
Participants with amyotrophic lateral sclerosis are observed over time to track disease progression and related genetic factors.
Periodic visits throughout the study duration
Trial Site Locations
Total: 1 location
1
Department of Neurology, First Affiliated Hospital of Fujian Medical University
Fuzhou, Fujian, China, 350005
Actively Recruiting
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Research Team
Q
Qi-Jie Zhang, PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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