Actively Recruiting
A Registered Observational Cohort Study on Neurodegenerative Associated With Sleep Disorder
Led by Fujian Medical University Union Hospital · Updated on 2025-01-22
500
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Cognitive problems often occur in people with neurodegenerative diseases. Researchers are exploring how sleep disorders relate to the progression of these diseases by studying their clinical signs, brain imaging, and biological markers. This observational study aims to better understand the mechanisms behind sleep problems in neurodegenerative conditions. Participants will have assessments including neuropsychological tests, brain MRI scans, and electroencephalograms. Biological samples will also be collected to measure markers like plasma Ab2-42 levels. These evaluations will help observe changes in sleep quality, cognitive function, heart rate variability, and other relevant outcomes over time. People in the study will undergo baseline and follow-up tests such as the Pittsburgh Sleep Quality Index (PSQI), Montreal Cognitive Assessment (MoCA), and Addenbrooke's Cognitive Examination (ACE-III). Researchers will monitor sleep patterns and biological markers to track disease progression. The study includes adults aged 30 to 80 years and will continue through June 2030, providing long-term data on sleep disorders linked to neurodegeneration.
CONDITIONS
Brief Title
A Registered Cohort Study on Neurodegenerative Associated With Sleep Disorder.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Clinical diagnosis of neurodegenerative disease.
- Experience of insomnia, excessive drowsiness, or confusion at night.
- Frequent awakenings, daily sleep episodes, or nocturnal confusion.
- Presence of one or more: wandering at night with inappropriate activity, agitation or combativeness, confusion or marked delirium.
- Polysomnographic monitoring showing poor sleep efficiency and increased number and duration of awakenings.
- Multiple sleep latency tests showing increased daytime sleepiness.
- Presence of other medical symptoms not indicating the primary disease.
- Other sleep disorders may be present but do not explain main symptoms.
- Diagnosis can be made based on any of the above.
You will not qualify if you...
- Patients with other neurological disorders.
- Pregnant or lactating women.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Baseline
Participants undergo neuropsychological assessments, brain MRI, electroencephalogram, and biomarker data collection to evaluate neurodegenerative disorders associated with sleep disorders.
1 visit (in-person)
Duration - 1 year
Participants are monitored to observe changes in cognitive and sleep-related measures over time.
1 follow-up visit at 1 year after baseline
Trial Site Locations
Total: 1 location
1
Fujian Medical University Union Hospital
Fuzhou, Fujian, China, 350000
Actively Recruiting
Research Team
X
Xiaodong Pan, Doctor
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
Frequently Asked Questions
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