Actively Recruiting
Registry on Augmented Antithrombotic Treatment Regimens for Patients With Arterial Thrombotic APS
Led by McMaster University · Updated on 2025-12-09
150
Participants Needed
3
Research Sites
391 weeks
Total Duration
On this page
Sponsors
M
McMaster University
Lead Sponsor
I
International Society on Thrombosis and Haemostasis
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this registry is to gather more information on the efficacy and safety of various antithrombotic regimens. The registry collects data on patients with antiphospholipid syndrome and an arterial event within the past 12 months, on treatment with either A) a VKA with therapeutic range, INR 2.0-3.0 plus low-dose aspirin (75-100 mg daily), B) a VKA alone with therapeutic range, INR 2.0-3.0, C) a VKA with therapeutic range, INR 3.0-4.0, or D) with a dual antiplatelet regimen. The follow-up is 2 years.
CONDITIONS
Official Title
Registry on Augmented Antithrombotic Treatment Regimens for Patients With Arterial Thrombotic APS
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged 18 years or older with confirmed antiphospholipid syndrome according to Sydney criteria
- First or recurrent arterial thrombotic event, including asymptomatic brain infarcts
- Receiving treatment with either vitamin K antagonist plus low-dose aspirin, vitamin K antagonist alone (INR 2.0-3.0), vitamin K antagonist alone (INR 3.0-4.0), or dual antiplatelet therapy
- Signed informed consent obtained where required
You will not qualify if you...
- Unable to follow the patient due to geographic or other reasons
- Documented poor compliance
- Bleeding risk considered unsafe for combination antithrombotic therapy by treating physician
- Pregnant or planning pregnancy
- Venous thrombotic event diagnosed after last arterial event
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 3 locations
1
Instituto de Investigaciones en Salud Pública, Universidad de Buenos Aires
Buenos Aires, Buenos Aires F.D., Argentina, C1113 AAJ
Actively Recruiting
2
Clinica Universitaria Reina Fabiola
Córdoba, Argentina
Actively Recruiting
3
McMaster University
Hamilton, Ontario, Canada, L9H 7M1
Actively Recruiting
Research Team
S
Sam Schulman, MD, PhD
CONTACT
H
Hannah Cohen, MD, FRCP
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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