Actively Recruiting
A Registry-Based Cohort Study on the Clinical Outcomes of Spinal Cord Glioma Resection Via the Dorsolateral Sulcus Approach
Led by Beijing Tiantan Hospital · Updated on 2025-07-23
100
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Spinal cord gliomas are rare malignant tumors that develop within the spinal cord, often appearing around age 35 and slightly more common in males. These tumors typically cause symptoms like axial pain and tend to grow in a lateral, infiltrative pattern. Treatments are limited mainly to surgery, and the choice of surgical approach can affect neurological outcomes and quality of life. This research compares two surgical methods to find the best approach for tumor removal and patient recovery. The study compares the dorsolateral sulcus (DLS) approach and the traditional posterior median sulcus (PMS) approach for spinal cord tumor removal. The DLS approach is thought to better preserve neurological function by avoiding critical midline structures, while the PMS approach offers direct midline access but risks more damage. Patients with laterally located tumors, confirmed by imaging and pathology, undergo surgery via one of these two methods. Outcomes will be assessed over time to evaluate pain, neurological function, quality of life, tumor removal extent, and survival. Participants will be evaluated before surgery and followed up at 1, 3, 6, and 12 months after surgery with clinical exams, imaging, and questionnaires like the Visual Analog Scale for pain and SF-36 for quality of life. Neurological function is measured using established grading scales, and tumor progression and survival are monitored up to 24 and 36 months, respectively. The study aims to determine which surgical approach best balances effective tumor removal with preservation of neurological health.
CONDITIONS
Brief Title
A Registry-Based Cohort Study on the Clinical Outcomes of Spinal Cord Glioma Resection Via the Dorsolateral Sulcus Approach
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 3 and 75 years
- Undergoing surgical resection of spinal cord tumor
- Histopathological diagnosis of spinal cord glioma based on routine pathological examination
- Availability of complete clinical data and willingness to participate in follow-up
- Informed consent obtained from the patient and/or legal guardians or immediate family members
You will not qualify if you...
- Age under 3 years or over 75 years
- Receipt of radiotherapy, chemotherapy, or anti-tumor biological therapy within 1 month prior to enrollment
- Receipt of immunotherapy within 3 months prior to enrollment
- Participation in other clinical trials within 3 months prior to enrollment
- History of severe allergic reactions or known allergy-prone constitution
- Pregnant or breastfeeding women, or individuals of childbearing potential not using adequate contraception
- Presence of other severe medical conditions or uncontrolled infections
- History of drug abuse, substance misuse, chronic alcoholism, or HIV infection
- Uncontrolled epileptic seizures or psychiatric disorders resulting in loss of self-control
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Day of surgery and hospital stay following surgery
Participants undergo surgical resection of spinal cord glioma via either the dorsolateral sulcus or posterior median sulcus approach, followed by immediate postoperative care.
1 surgical visit and hospital stay
Duration - Up to 36 months after surgery
Participants are assessed at multiple time points after surgery to evaluate neurological recovery, pain levels, and quality of life using clinical scales and imaging.
Visits at 1 month, 3 months, 6 months, 12 months, and last follow-up up to 36 months
Trial Site Locations
Total: 1 location
1
Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University
Beijing, Beijing Municipality, China, 100070
Actively Recruiting
Research Team
W
Wang Yongzhi Wang, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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