Long-Term Registry Study on Multimodal Treatment of Brain Arteriovenous Malformation in Mainland China Comparing Multidisciplinary Team-Based and Standard Care Approaches

What this Trial Is About

Researchers are conducting a multi-center, prospective registry study to explore the long-term outcomes of brain arteriovenous malformations AVMs in mainland China. This observational study, supported by the National Key Research and Development Program, aims to find standardized diagnosis and treatment processes by comparing patients treated with and without a multidisciplinary team approach. The study involves patients aged 1 to 80 years who have confirmed AVM diagnoses using advanced imaging techniques such as digital subtraction angiography and MRI. Participants are divided into two groups an experimental group receiving treatment planned by a multidisciplinary team and a control group treated without such a protocol. Treatments include craniotomy, embolization, and stereotactic radiosurgery based on detailed preoperative evaluations. The multidisciplinary team follows strict treatment criteria depending on whether AVMs are ruptured or unruptured, recommending surgery, embolization, radiosurgery, or conservative care accordingly. The control group includes patients treated before the multidisciplinary team was established or without comprehensive evaluation. Patients data, including baseline characteristics, imaging, surgical information, and follow-up outcomes, are collected through an electronic data capture system. Neurofunctional assessments occur at baseline, 3 months, 12 months, and 3 years post-treatment, evaluating outcomes such as the modified Rankin Scale, AVM obliteration rates, hemorrhage occurrence, and complication rates. Researchers also monitor improvements in epilepsy, headache, and neurological function over time. Follow-ups are conducted via clinical visits and telephone interviews, with imaging reviewed by experienced radiologists.

Registry of Multimodality Treatment for Brain Arteriovenous Malformation in Mainland China