Observational Study of First-Line Palliative Systemic Treatment and Quality of Life in Patients with Metastatic Esophageal, Gastric, or Gastroesophageal Junction Cancer in Germany

What this Trial Is About

This study is a national, observational research project focusing on patients with metastatic esophageal, gastric, or gastroesophageal junction cancer in Germany. It aims to collect detailed information on antineoplastic treatments given with palliative intent in routine clinical practice. The goal is to understand the common treatment sequences, changes over time, and their outcomes, especially quality of life, in patients receiving systemic therapy for these cancers. Participants receive routine care based on their physicians choice and clinical needs, reflecting standard treatments used in daily practice. The study follows patients for up to two years, documenting all systemic treatments, radiotherapy, surgeries, and related outcomes longitudinally. No experimental treatments are assigned, as this is an observational study capturing real-world clinical data. Throughout the study, data on patient characteristics, tumor details, comorbidities, and prior treatments are collected at the start. During follow-up, researchers monitor treatments and outcomes, including health-related quality of life, via questionnaires and medical records. The primary outcome is the course of treatment over two years. Participants usual care continues uninterrupted, and data collection helps provide a comprehensive picture of treatment patterns and patient experiences.

Registry Platform Gastric/Esophageal Cancer (SAPHIR)