Actively Recruiting
A Registry Study on Biomarkers of Takayasu's Arteritis
Led by Beijing Institute of Heart, Lung and Blood Vessel Diseases · Updated on 2022-04-12
1000
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
B
Beijing Institute of Heart, Lung and Blood Vessel Diseases
Lead Sponsor
S
Shanghai Zhongshan Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
Takayasu arteritis is a rare, chronic inflammation of the large arteries such as the aorta and its main branches. This condition can cause narrowing, blockage, or stretching of these vessels, sometimes leading to aneurysms. It often affects young Asian women and may remain undetected until vascular problems arise. Because many people with Takayasu arteritis show no clear symptoms despite active disease, researchers are seeking new biomarkers to improve diagnosis and monitor disease activity, aiming to better understand its underlying biological processes. This observational study focuses on identifying these biomarkers by enrolling individuals diagnosed with or suspected of having Takayasu arteritis. Participants include cases who meet specific classification criteria and controls. The study collects data retrospectively and prospectively, using imaging techniques like vascular magnetic resonance angiography or computed tomography angiography instead of traditional angiography. The study monitors disease status over time to uncover biochemical markers linked to disease activity. Participants will have their diagnosis and disease activity recorded from medical records within about three to six months after sample collection. These records and follow-up visits help assess the progression and activity of the disease. The study involves reviewing clinical data and imaging results to support biomarker discovery. Participation duration and follow-up depend on individual cases, with researchers closely tracking disease status to enhance understanding of Takayasu arteritis.
CONDITIONS
Brief Title
A Registry Study on Biomarkers of Takayasu's Arteritis (ARSBTA)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Subjects who meet the American College of Rheumatology 1990 classification criteria for Takayasu arteritis, including at least 3 of the following: age of onset 40 years or younger, claudication of upper or lower limbs, decreased pulse in one or both brachial arteries, systolic blood pressure difference of 10 mmHg or more between arms, bruit over subclavian arteries or aorta, and imaging evidence of aortic branch stenosis or occlusion
- Adults aged 18 to 70 years
- Subjects with initial suspicion of Takayasu arteritis or needing assessment of disease activity (prospective enrollment)
You will not qualify if you...
- Arteriographic lesions entirely due to atherosclerosis
- Presence of other autoimmune diseases like ANCA-associated vasculitis or systemic lupus erythematosus
- Diagnosis of Cogan's syndrome or Behcet's disease
- Any serious acute or chronic infection
- Giant cell arteritis or other infectious large vessel vasculitis
- Patients without image studies (prospective enrollment)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - At enrollment
Biological samples are collected from participants to analyze biomarkers related to Takayasu's Arteritis.
1 visit (in-person)
Duration - Approximately 6 months
Participants are monitored for disease diagnosis and activity through medical record reviews and follow-up visits.
1 to 2 visits depending on disease activity assessment
Trial Site Locations
Total: 1 location
1
Beijing Anzhen Hospital
Beijing, Beijing Municipality, China, 100029
Actively Recruiting
Research Team
Y
Yuan WANG, PhD
F
Fengjuan LI, PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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