Actively Recruiting
The Registry Study of Genetic Alterations of Melanoma in Taiwan
Led by National Health Research Institutes, Taiwan · Updated on 2025-05-06
250
Participants Needed
16
Research Sites
436 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Cutaneous melanoma is the most aggressive malignancy in skin cancers. Cutaneous melanoma is a rare disease in Taiwan with an incidence rate of around 1/100,000. Acral lentiginous melanoma is the most common subtype and comprises more than half of cutaneous melanoma in Asia including Taiwan but only 1% in Caucasians. In addition, mucosal melanoma accounts for more than 20% of malignancy melanoma in Taiwan but only 1% in Caucasians. Acral and mucosal melanomas have distinct epidemiological, clinical, pathological and genetic features from non-acral melanoma which is commonly seen in Western countries. Comparing with melanoma in Caucasians, Asian melanoma has higher recurrence rate after primary surgery, lower response rate to immunotherapy, and shorter progression-free survival for immunotherapy and targeted therapy leading generally poor survival outcomes regardless stage.
CONDITIONS
Official Title
The Registry Study of Genetic Alterations of Melanoma in Taiwan
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age over 18 years old
- Pathologically confirmed melanoma
- ECOG performance status less than 3
- Melanoma stage I to IV, including early, locally advanced resectable, unresectable/metastatic, or recurrent melanoma based on AJCC 8th edition
- Willingness to provide archival or new tumor tissue samples for the study
- Life expectancy more than 3 months
- Ability and willingness to understand the study and attend regular follow-up visits
You will not qualify if you...
- Inability to provide a complete medical history
- No available tumor tissue for genetic testing or tissue sample older than 5 years
- Mental status not suitable for treatment or data collection leading to poor compliance
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 16 locations
1
Taipei Veterans General Hospital
Taipei, Taiwan/Taipei, Taiwan
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2
CHANG GUNG MEMORIAL HOSPITAL, Chiayi
Chiayi City, Taiwan
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3
Kaohsiung Chang Gung Memorial Hospital
Kaohsiung City, Taiwan
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4
Kaohsiung Medical University
Kaohsiung City, Taiwan
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5
National Taiwan University Hospital ,NTUH Hsin-Chu Branch
Sindian City, Taiwan
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6
China Medical University Hospital
Taichung, Taiwan
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7
Chung Shan Medical University Hospital
Taichung, Taiwan
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8
Taichung Veterans General Hospital
Taichung, Taiwan
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9
National Cheng Kung University Hospital
Tainan, Taiwan
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10
Koo Foundation Sun Yat-Sen Cancer Center
Taipei, Taiwan
Actively Recruiting
11
MacKay Memorial Hospital
Taipei, Taiwan
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12
National Taiwan University Hospital
Taipei, Taiwan
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13
Taipei Medical University -Ministry of Health and Welfare Shuang-Ho Hospital
Taipei, Taiwan
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14
Wan Fang Hospital, Taipei Medical University
Taipei, Taiwan
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15
CHANG GUNG MEMORIAL HOSPITAL, Linkou
Taoyuan, Taiwan
Actively Recruiting
16
Taoyuan General Hospital, Ministry of Health and Welfare
Taoyuan, Taiwan
Actively Recruiting
Research Team
C
Chien-Ya Hung, BS
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
4
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