Actively Recruiting
REGULUS: MRI-guided Adaptive SABR for Liver Cancers
Led by Stanford University · Updated on 2026-02-09
62
Participants Needed
1
Research Sites
205 weeks
Total Duration
On this page
Sponsors
S
Stanford University
Lead Sponsor
V
Viewray Inc.
Collaborating Sponsor
AI-Summary
What this Trial Is About
Single arm unblinded study of simulation-free MRI-guided SABR with adaptive replanning in one session for treatment of patients with liver cancers
CONDITIONS
Official Title
REGULUS: MRI-guided Adaptive SABR for Liver Cancers
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Histologically confirmed hepatocellular carcinoma, intrahepatic cholangiocarcinoma, or metastatic cancer. For suspected HCC with known cirrhosis, diagnosis may be based on noninvasive criteria or LI-RADS score of 5
- 18 years or older at enrollment
- Child-Pugh A liver function status
- Eastern Cooperative Oncology Group (ECOG) Performance Status of 0, 1, or 2
- Life expectancy greater than 6 months
- Negative urine or serum pregnancy test for women of childbearing potential or who are not postmenopausal
- Ability to understand and willing to provide written informed consent
- Prior liver-directed therapies allowed except radioembolization if other criteria are met
You will not qualify if you...
- Prior treatment with radioembolization
- Cytotoxic chemotherapy or investigational agent within 1 week before SABR
- Prior radiotherapy overlapping with the treatment site
- Pregnant female patients
- Contraindications to MRI or inability to tolerate MRI
- Presence of a pacemaker or other implanted cardiac device
- Tumor directly extending into stomach, duodenum, small bowel, or large bowel
- Inability to hold breath for more than 15 seconds
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Stanford University
Palo Alto, California, United States, 94304
Actively Recruiting
Research Team
E
Eleanor Brown
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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