Actively Recruiting
Rehab and Mechanical Ventilation
Led by University of Florida · Updated on 2026-05-05
16
Participants Needed
1
Research Sites
91 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this research study is to evaluate the effects of a single session of rehabilitation in healthy adults, before noninvasive mechanical ventilation (MV). MV can help support breathing function during sleep or illness. High levels of MV support have been reported to alter the function of the diaphragm muscle, the primary breathing muscle, in people with compromised health. However, rehabilitation may have some potential to improve diaphragm function in advance of using MV. This study will test different rehabilitation interventions, including (1) inspiratory strength training (IST), (2) transcutaneous spinal cord stimulation (TSCS), or sham TSCS. Before and after MV, participants will complete breathing strength tests and responses to phrenic nerve stimulation.
CONDITIONS
Official Title
Rehab and Mechanical Ventilation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Non-smokers
- Sedentary or recreationally active individuals
- Normal lung function
- No history of claustrophobia
You will not qualify if you...
- Current smoking or vaping
- Obstructive lung disease
- Use of antibiotics or systemic corticosteroids for acute conditions
- History of sepsis or metastatic disease
- Post infectious conditions affecting breathing
- Diagnosed neurological or neuromuscular conditions
- Use of supplemental oxygen, CPAP, or other positive pressure ventilation for sleep apnea
- Cardiac disease
- Orthopedic conditions impairing lung expansion
- Pregnancy
- Implanted metallic devices within 10 cm of the cervical spine
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Florida
Gainesville, Florida, United States, 32610
Actively Recruiting
Research Team
B
Barbara K Smith, PhD, PT
CONTACT
U
Ushna Khan, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
3
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