Actively Recruiting
Rehabilitation After a Hip Fracture: the Effects of Dietary Protein and Exercise on Bone and Muscle Health and Quality of Life
Led by Wageningen University · Updated on 2025-06-25
102
Participants Needed
2
Research Sites
99 weeks
Total Duration
On this page
Sponsors
W
Wageningen University
Lead Sponsor
R
Rijnstate Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
Hip fractures often lead to functional limitations, loss of independence, weight loss and decreased well-being. Only half of the patients regain their functional level and 24% die within the following year. Financial consequences are significant due to costly surgery and long-term care. Hip fracture incidence is expected to increase sharply due to the ageing population, reducing accessibility to and quality of rehabilitation care. Therefore, optimizing treatment is essential. Previous protein and exercise studies showed improved muscle and bone health in healthy or frail community-dwelling older adults, but effects in older hip fracture patients are not known. Better rehabilitation may improve bone and muscle health, nutritional status, quality of life, lower costs and lower burden for healthcare. The overall objective is to investigate the effectiveness, costs and cost-effectiveness of a protein-enriched diet and resistance exercise for 3 months compared to usual care on bone and muscle health, and quality of life in older adults recovering from an acute hip fracture.
CONDITIONS
Official Title
Rehabilitation After a Hip Fracture: the Effects of Dietary Protein and Exercise on Bone and Muscle Health and Quality of Life
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 65 years or older
- Acute hip fracture
- Able to provide written informed consent
- Mentally competent as assessed by the treating physician
- Admitted to a participating rehabilitation centre
You will not qualify if you...
- Allergy, intolerance, or hypersensitivity to milk or lactose (self-reported)
- Unwilling to stop dietary supplements except calcium and vitamin D
- Pathological or periprosthetic fracture
- Abnormal liver or kidney function (eGFR <30 ml/min/1.73 m2)
- Diagnosed with conditions where high protein intake is harmful (e.g., renal failure, liver disease)
- Diagnosed bone metabolic disorders such as primary hyperparathyroidism, Paget's disease, or myeloma
- Using medications other than bisphosphonates that strongly affect bone, calcium, or muscle metabolism
- Having disorders that prevent following study protocol without caregiver help
- Currently participating in other scientific research
- No permission to access medical history and related information from healthcare providers
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 2 locations
1
Rijnstate Hospital
Arnhem, Netherlands, 6851AD
Actively Recruiting
2
Gelderse Vallei Hospital
Ede, Netherlands, 6716RP
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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