Actively Recruiting
Rehabilitation Exercise and Education of Airway Clearance Technique in Nontuberculous Mycobacterial Pulmonary Disease: A Prospective Cohort Study
Led by Seoul National University Bundang Hospital ยท Updated on 2025-06-29
500
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the effects of pulmonary rehabilitation and airway clearance education in adults diagnosed with nontuberculous mycobacterial pulmonary disease (NTM-PD). This observational study aims to find out whether these non-drug treatments can improve lung function, relieve symptoms, enhance quality of life, and increase sputum culture conversion rates in patients with NTM-PD. The study is designed to provide evidence that may guide future management of this lung condition. Participants will take part in an 8-week pulmonary rehabilitation program with biweekly sessions. The program includes techniques such as oscillating positive expiratory pressure (OPEP) therapy, high-frequency chest wall oscillation (HFCWO), huffing and coughing methods, breathing exercises, and aerobic and strength training. They will be evaluated at the start, during the intervention, and followed up at 2 months and 6 months after treatment. Throughout the study, participants will undergo pulmonary function tests (measuring FEV1 and FVC), bacteriologic assessments, chest imaging (CT/X-ray), symptom evaluations, and quality of life surveys including EQ-5D-5L and the COPD Assessment Test (CAT) score. Researchers will monitor changes in lung function, sputum culture conversion, exercise capacity (6-minute walk test), and radiographic severity. The total participation period includes these assessments from baseline to 6 months post-intervention.
CONDITIONS
Brief Title
Rehabilitation Exercise and Education of Airway Clearance Technique in NTM-PD: A Prospective Cohort Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 20 years or older at the time of enrollment.
- Diagnosis of nontuberculous mycobacterial pulmonary disease (NTM-PD) according to the 2020 American Thoracic Society (ATS) guidelines.
- Identification of clinically significant NTM species, including Mycobacterium avium, Mycobacterium intracellulare, Mycobacterium abscessus, Mycobacterium massiliense, and Mycobacterium kansasii.
- Able to undergo pulmonary rehabilitation and airway clearance training as part of the study protocol.
- Willing to provide written informed consent to participate in the study.
You will not qualify if you...
- Currently pregnant or actively breastfeeding.
- Unable to participate in pulmonary rehabilitation due to severe mobility impairment or neuromuscular disorders.
- History of massive hemoptysis or other medical conditions where airway clearance techniques may be contraindicated.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 day
Participants undergo baseline assessments including pulmonary function tests, bacteriologic assessments, radiographic imaging, symptom evaluations, and quality of life assessments before starting pulmonary rehabilitation and airway clearance training.
1 visit (in-person)
Duration - 8 weeks
Participants attend an 8-week biweekly pulmonary rehabilitation program that includes oscillating positive expiratory pressure therapy, high-frequency chest wall oscillation, huffing and coughing techniques, breathing exercises, and aerobic/strength training.
Biweekly visits for 8 weeks
Duration - 6 months
Participants are assessed during treatment and at 2-month and 6-month follow-ups with pulmonary function tests, bacteriologic assessments, radiographic imaging, symptom evaluations, and quality of life assessments to evaluate the effectiveness of the rehabilitation program.
3 visits (baseline, 2 months, and 6 months)
Trial Site Locations
Total: 1 location
1
Seoul National University Bundang Hospital
Seongnam-si, Gyeonggi-do, South Korea, 13620
Actively Recruiting
Research Team
H
Hyung-Jun Kim, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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