Actively Recruiting
Rehabilitation and Longitudinal Follow-up of Cognition in Adult Lower Grade Gliomas
Led by University of California, San Francisco · Updated on 2026-01-26
97
Participants Needed
1
Research Sites
355 weeks
Total Duration
On this page
Sponsors
U
University of California, San Francisco
Lead Sponsor
T
Tilburg University
Collaborating Sponsor
AI-Summary
What this Trial Is About
Patients with glial brain tumors have increasingly improved outcomes, with median survival of 5-15 years. However, the treatments, including surgery, radiation, and chemotherapy, often lead to impaired attention, working memory, and other cognitive functions. These cognitive deficits frequently have significant impact on patient quality of life. Although currently, there is no established standard of care to treat cognitive deficits in brain tumor patients, standard cognitive rehabilitative treatments have been developed for those with traumatic brain injury and stroke. However, the feasibility and efficacy of these cognitive treatments in individuals with brain tumors remains unclear.
CONDITIONS
Official Title
Rehabilitation and Longitudinal Follow-up of Cognition in Adult Lower Grade Gliomas
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Histologically confirmed low grade supratentorial primary brain tumor
- 18 years old or older
- Life expectancy greater than 12 weeks
- Karnofsky performance status (KPS) of 70 or higher
- Fluent in spoken and written English
- Access to the internet
- Text-enabled cellphone
- Receiving MRI scans at University of California, San Francisco (UCSF)
- Clinically stable and off treatment (radiation or chemotherapy) for at least 3 months
- At least 6 months from craniotomy
- Subjective complaints of cognitive deficits
- Adequate seizure control and on stable or decreasing dose of anti-epileptics
- Scoring 1 standard deviation or less below normal on two or more baseline neuropsychological assessment domains
- Presumed low grade primary brain tumor with surgery planned or within 4 months post-surgery
- Plan to continue neuro-oncology care at UCSF
You will not qualify if you...
- Diagnosis or evidence of glioblastoma
- Diagnosis or evidence of extra-axial disease (e.g., meningioma)
- Diagnosis or evidence of infra-tentorial disease
- Unable to comply with study or follow-up procedures
- Unable to complete or score 3 or more cognitive tests at baseline
- Acutely suicidal, psychotic, or gravely disabled
- Neuropsychologist's opinion that significant neurologic deficit prevents participation in testing or rehabilitation
- Acute psychiatric issues such as suicidality, active psychosis, or grave disability
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
University of California, San Francisco
San Francisco, California, United States, 94143
Actively Recruiting
Research Team
J
Jennie Taylor, MD, MPH
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
SINGLE_GROUP
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
6
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