Actively Recruiting
Relation Between Psychoactive Drugs Overdosage and Severity of Falls in Elderly People
Led by University Hospital, Caen · Updated on 2025-07-25
400
Participants Needed
1
Research Sites
209 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
There are many epidemiological data on the relationship between the number or nature of psychoactive medications used and the risk of falling in elderly, but very little on the relationship between the amount of psychoactive medication actually present in the blood and the severity of the fall. However, the inevitable drug-drug interactions related to polypharmacy and the pharmacokinetic modifications related to old age may lead plasma overdose situations which can potentiate the risk of falls but also aggravate these consequences. The investigators therefore propose a study with the objective of verifying whether the proportion of falls with serious traumatic consequences is more frequent in patients over 75 years old, presenting plasma overdoses of psychoactive drugs (plasma concentrations higher than the usual therapeutic concentrations) in regard to those between therapeutic ranges. The aim of this work is to verify if the falls present more severe characters when the psychoactive drug concentrations are beyond the usual therapeutic ranges.
CONDITIONS
Official Title
Relation Between Psychoactive Drugs Overdosage and Severity of Falls in Elderly People
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged 75 years or older admitted to the emergency room for a fall and planned for hospitalization
- Patients taking at least one psychoactive drug listed in the study protocol
- Patients able to move before hospitalization, with or without technical assistance
- Patients who have signed informed consent
- Patients covered by the social security system
You will not qualify if you...
- Patients not requiring hospitalization after the emergency room visit
- Patients who fell more than 12 hours before study inclusion (blood sampling)
- Patients with Parkinson's disease or who fell following a convulsive seizure
- Patients with a very short-term life-threatening prognosis (e.g., in shock or palliative care planned from emergency room)
- Patients who are wheelchair-bound or bedridden
- Adults under legal protection such as guardianship or curatorship
- Patients who do not understand the French language
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Caen University Hospital
Caen, France
Actively Recruiting
Research Team
V
Véronique Lelong-Boulouard, PhD
CONTACT
C
Cédric Villain, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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