Actively Recruiting
Relationship of Airway Microbiota, Endotype and Phenotype in Adult Asthma
Led by Chinese University of Hong Kong · Updated on 2026-03-19
140
Participants Needed
1
Research Sites
340 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Increasing evidence supports that the respiratory microbiota, including viral and bacterial microorganisms, play important roles in respiratory health and disease. Microbial patterns in airways may induce distinctive endotypes of asthma. Previous studies suggest host-microbiota interactions in children may account for the heterogeneity of endotypes and clinical presentations. However, information on such relationship is limited in adults. Furthermore, how the upper airway microbiome is related to asthma endotype and phenotype is not well understood. Knowledge of microbiota in the airway allows exploration of therapeutic manipulation of the microbiome and targeting the development of asthma prevention strategies and the optimization of asthma treatment.
CONDITIONS
Official Title
Relationship of Airway Microbiota, Endotype and Phenotype in Adult Asthma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Subjects aged between 18 and 80 years with a diagnosis of asthma according to the Global Initiative for Asthma (GINA) 2020.
- Asthma diagnosis confirmed by history and documented evidence of variable airflow obstruction, including an increase in FEV1 greater than 12% or 200 mL after bronchodilator or bronchial hyperresponsiveness on testing, when stable.
You will not qualify if you...
- Patients with other known respiratory diseases such as chronic obstructive pulmonary disease, bronchiectasis, tuberculosis-destroyed lung, history of lung resection, or lung cancer.
- Individuals older than 40 years with more than 10 pack-years smoking history or significant biomass exposure.
- Patients currently enrolled in other clinical studies.
- Pregnant women.
- Current smokers who have not quit smoking in the past year.
- Use of systemic or intranasal antibiotics within 4 weeks.
- Signs or symptoms of upper or lower respiratory tract infections within 4 weeks.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Prince of Wales Hospital
Shatin, Hong Kong
Actively Recruiting
Research Team
F
Fanny Ko, MD
CONTACT
D
David Hui, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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