Actively Recruiting
Relationship Between Abnormal Myocardial Perfusion and Diastolic Dysfunction in Sickle Cell Disease Using PET
Led by St. Jude Children's Research Hospital · Updated on 2026-05-06
40
Participants Needed
1
Research Sites
255 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
There is limited information on what causes injury to the heart in individuals with Sickle Cell Disease (SCD). Researchers in this study want to see if decreased blood flow to the heart during stress could be causing the heart damage seen in SCD patients. They also want to test people who don't have SCD to see if their hearts react the same way under stress. Primary Objective * To estimate the coronary flow reserve (CFR) (also referred to as myocardial perfusion reserve), as measured by PET stress-rest myocardial perfusion imaging, in SCD patients with and without diastolic dysfunction, and healthy controls. Secondary Objectives * To investigate the relationship between decreased CFR (quantified with PET stress- rest myocardial perfusion imaging) and presence of abnormal diastolic parameters
CONDITIONS
Official Title
Relationship Between Abnormal Myocardial Perfusion and Diastolic Dysfunction in Sickle Cell Disease Using PET
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 21 years
- Black race
- Diagnosis of Sickle Cell Disease (HbSS or HbSβ0 thalassemia) for Stratum A and B
- For Stratum A: Three or more abnormal diastolic parameters based on American Society of Echocardiography guidelines
- For Stratum B: Two or fewer abnormal diastolic parameters
- For Stratum C (healthy controls): Black race, age 18-21, two or fewer abnormal diastolic parameters
You will not qualify if you...
- Recent hospitalization for vaso-occlusive pain crisis or acute chest syndrome within 4 weeks
- Blood transfusion within the last 3 months
- Signs, symptoms, or EKG findings of acute myocardial ischemia, infarction, or unstable angina
- History of ventricular tachycardia/fibrillation (VT/VF) or supraventricular tachycardia (SVT)
- Previous cardiac surgery
- Known congenital heart disease except patent ductus arteriosus or atrial septal defect
- Stenotic valvular disease or left main coronary artery stenosis
- History of myocarditis or pericarditis
- Left ventricle systolic dysfunction
- Cardiovascular instability or uncontrolled hypertension
- History of sinus node dysfunction or high-grade AV nodal block
- History of aborted sudden cardiac death or cardiac arrest
- Current seizure disorder on anti-epileptic drugs
- Pregnant or breastfeeding
- Any medical or social condition making participation ill-advised as judged by the investigators
- For Stratum B: Diagnosis of three or more abnormal diastolic parameters
- For Stratum C: Any genotype of SCD or anemia grade 2 or worse at study visit 1
AI-Screening
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Trial Site Locations
Total: 1 location
1
St. Jude Children's Research Hospital
Memphis, Tennessee, United States, 38105
Actively Recruiting
Research Team
P
Parul Rai, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
DIAGNOSTIC
Number of Arms
3
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