Actively Recruiting
Relationship Between Aspirin Metabolism and Markers of Metabolic Dysfunction Among Pregnant Persons at Risk of Pre-eclampsia
Led by University of Tennessee Graduate School of Medicine · Updated on 2025-09-10
50
Participants Needed
1
Research Sites
208 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study's primary purpose is to determine the relationship between aspirin metabolism and markers of metabolic dysfunction among patients at risk for preeclampsia.
CONDITIONS
Official Title
Relationship Between Aspirin Metabolism and Markers of Metabolic Dysfunction Among Pregnant Persons at Risk of Pre-eclampsia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Recommended aspirin for pre-eclampsia prevention by OB/GYN or MFM specialist based on ACOG and USPSTF guidelines (1 high risk factor, 2+ moderate risk factors)
- Willingness to adhere to aspirin therapy
- Willingness to undergo 2-hour oral glucose tolerance test for serum and urine collection, surveys, indirect calorimetry, body composition measures, and neonatal assessments
- Gestational age at enrollment less than 16 weeks
- Ability to speak, read, and communicate in English
You will not qualify if you...
- Type 2 Diabetes Mellitus
- Type 1 Diabetes Mellitus
- Current gestational diabetes mellitus
- Current or active platelet disorder or bleeding diathesis including thrombocytopenia, idiopathic thrombocytopenic purpura, thrombotic thrombocytopenic purpura, von Willebrand disease, etc.
- Thrombophilia
- Current use of NSAIDs for other indications such as indomethacin or ibuprofen
- Current use of other immune-modulating agents and biologics like hydroxychloroquine, azathioprine, 6-mercaptopurine, IL-6 inhibitors
- Current or recent use of steroids
- Current use of prophylactic or therapeutic anticoagulation
- Medical contraindication to aspirin therapy
- Molar pregnancy
- Renal disease
- Inability or unwillingness to give informed consent
- Current psychiatric illness or social situation that would limit compliance with study requirements, as determined by the principal investigators
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Tennessee Medical Center
Knoxville, Tennessee, United States, 37920
Actively Recruiting
Research Team
J
Jill M Maples, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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