Actively Recruiting
Relationship Between Great Toe Strength And Symptoms of Chemotherapy-Induced Peripheral Neuropathy (CIPN)
Led by University of Florida · Updated on 2026-02-10
30
Participants Needed
1
Research Sites
73 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Great Toe Strength (GTS) is a potential clinical biomarker that has been associated with functional mobility and health; Additionally, GTS has been identified in the literature as one of the early symptoms of chemotherapy-induced peripheral neuropathy (CIPN). The purpose of this research study is to evaluate GTS in individuals with CIPN and healthy adults using ToeScale and see how it relates to nerve issues from chemotherapy. Additionally, we aim to assess the usability of the novel GTS assessment device, ToeScale among the participants. As a part of this study visit, you will complete some questionnaires followed by GTS and balance and gait assessments.
CONDITIONS
Official Title
Relationship Between Great Toe Strength And Symptoms of Chemotherapy-Induced Peripheral Neuropathy (CIPN)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 18 to 90 years old
- Ability to independently raise and lower (extend or flex) the great toe
- Able to consent and complete questionnaires in English independently with normal or corrected vision
- For CIPN group: Within 3 to 6 months of starting chemotherapy and confirmed CIPN diagnosis by nerve conduction study
- For healthy control group: No known health conditions affecting mobility, balance, or muscle strength, especially in the lower body
- Healthy controls matched by age and sex to CIPN participants
You will not qualify if you...
- Having comorbidities such as diabetes, arthritis, hypertension, thyroid disease, or heart disease linked to peripheral neuropathy or CIPN progression
- Toe deformities or impairments not caused by CIPN, including hallux valgus/varus, hallux limitus, hallux rigidus, hammer toe, claw toe, bunions, or webbed toes
- Self-reported past medical or surgical issues affecting strength of foot, ankle, or great toe
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Florida
Gainesville, Florida, United States, 32611
Actively Recruiting
Research Team
H
Hongwu Wang, PhD
CONTACT
R
Raghuveer Chandrashekhar, MS
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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