Assessment of Hidden Hearing Loss in Normal Hearing Individuals with and Without Tinnitus.
Eyyup Kara, Kübra Aydın, A Alperen Akbulut...
https://pubmed.ncbi.nlm.nih.gov/32209515Actively Recruiting
Age: 20Years - 60Years
All Genders
Healthy Volunteers
ID07230236
Investigation of the Relationship Between LS Chirp ABR and Comprehension In Noise Skills In Individuals With Suspected Hidden Hearing Loss
Led by Istanbul University - Cerrahpasa · Updated on 2025-11-17
63
Participants Needed
1
Research Sites
4 weeks
Total Duration
On this page
Sponsors
I
Istanbul University - Cerrahpasa
Lead Sponsor
M
Medipol University
Collaborating Sponsor
AI-Summary
What this Trial Is About
Hidden Hearing Loss (HHL) is a condition where people have normal hearing test results but struggle with understanding speech in noisy environments. This study investigates the relationship between auditory brainstem responses (ABR) elicited by Level-Specific CE-Chirp stimuli and speech-in-noise performance measured by the Hearing in Noise Test (HINT) in people suspected of having HHL. The research focuses on cochlear synaptopathy, a loss of nerve connections in the ear that affects hearing despite normal audiograms. Participants will be divided into three groups: those with normal hearing and no complaints, those with chronic tinnitus but normal hearing, and those with difficulties understanding speech in noise but without tinnitus. All will undergo ABR testing using LS CE-Chirp and click stimuli at various sound levels, as well as speech-in-noise testing with HINT. Testing includes cognitive screening, pure-tone audiometry, and other auditory assessments to ensure normal middle-ear function and exclude other conditions. During the study, participants will complete questionnaires and several hearing tests in a soundproof room. ABR recordings will be analyzed for wave amplitudes and latencies, while HINT will assess speech recognition in noise. The main goal is to correlate ABR wave measurements with speech-in-noise understanding. Results will help clarify the neural basis of HHL and may support future diagnostic and treatment approaches. The study is observational and will last until participant recruitment is complete, with data analyzed shortly after.
CONDITIONS
Brief Title
Relationship Between LS Chirp ABR and Speech-in-Noise Skills in Hidden Hearing Loss
Who Can Participate
Age: 20Years - 60Years
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- Be between 20 and 60 years of age
- Have normal bilateral pure-tone hearing thresholds (≤ 25 dB HL) at 0.5-4 kHz
- Score 21 or above on the Montreal Cognitive Assessment (MoCA) test
- Have no emotional or neurological problems that could interfere with testing
- For control group: no tinnitus or auditory complaints
- For first study group: chronic tinnitus lasting 3 months or more
- For second study group: no chronic tinnitus and below-normal scores on speech-in-noise perception questionnaire
You will not qualify if you...
- Have peripheral or central hearing loss
- Have somatosensory tinnitus
- Have emotional or neurological problems that could interfere with testing
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Diagnostic Evaluation
Duration - 1 day
Participants undergo a series of audiological and cognitive assessments including Montreal Cognitive Assessment (MoCA), pure-tone audiometry, immittance testing, and Threshold Equalizing Noise (TEN) test to confirm hearing status and eligibility.
1 visit (in-person)
Observational Testing
Duration - 1 day
Participants complete auditory brainstem response (ABR) testing using LS CE-Chirp and click stimuli, along with the Hearing In Noise Test (HINT) to evaluate neural synchrony and speech-in-noise comprehension.
1 visit (in-person)
Data Analysis and Correlation
Duration - Up to 1 month after participant recruitment completion
Collected data from ABR and HINT tests are analyzed to assess relationships between auditory neural responses and speech-in-noise performance.
No additional visits required
Trial Site Locations
Total: 1 location
1
Istanbul University-Cerrahpaşa
Istanbul, Turkey (Türkiye)
Actively Recruiting
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Research Team
C
Cem Yeral, MSc
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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https://pubmed.ncbi.nlm.nih.gov/26691159Adding insult to injury: cochlear nerve degeneration after "temporary" noise-induced hearing loss.
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Anna R Chambers, Jennifer Resnik, Yasheng Yuan...
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https://pubmed.ncbi.nlm.nih.gov/34942983Why do I hear but not understand? Stochastic undersampling as a model of degraded neural encoding of speech.
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https://pubmed.ncbi.nlm.nih.gov/25400543Hidden hearing loss: Fifteen years at a glance.
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https://pubmed.ncbi.nlm.nih.gov/38335624