Actively Recruiting
The Relationship Between Serum S100B and Brain-Derived Neurotrophic Factor
Led by Kanuni Sultan Suleyman Training and Research Hospital · Updated on 2026-04-15
60
Participants Needed
1
Research Sites
12 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Fibromyalgia is a chronic pain syndrome characterized by widespread musculoskeletal pain, fatigue, sleep disturbances, and cognitive symptoms. Central sensitization is considered a key mechanism in the pathophysiology of fibromyalgia; however, the underlying biological markers have not been fully clarified. Brain-derived neurotrophic factor (BDNF) and S100B protein have been suggested to play roles in neuroinflammation and central pain processing. This observational, cross-sectional study aims to evaluate serum S100B and BDNF levels in patients with fibromyalgia and to investigate their relationship with central sensitization and sleep quality. Serum biomarker levels and clinical assessment scales will be compared between patients with fibromyalgia and healthy controls.
CONDITIONS
Official Title
The Relationship Between Serum S100B and Brain-Derived Neurotrophic Factor
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Female participants aged between 18 and 50 years
- Diagnosis of fibromyalgia according to 2016 American College of Rheumatology criteria
- Symptoms present for at least 3 months
- Ability to understand and complete study questionnaires
- Provision of written informed consent
- For healthy controls: no diagnosis of fibromyalgia or chronic widespread pain
- For healthy controls: no known systemic disease
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Kanuni Sultan Süleyman Training and Research Hospital
Istanbul, Turkey (Türkiye)
Actively Recruiting
Research Team
Z
Zeynep Karakuzu Güngör, M.D
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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