Actively Recruiting
ReMARk: A Multi-level Intervention Addressing Disparities in Rural HPV-related Cancer Prevention: Part 3- Evaluation
Led by University of Florida · Updated on 2025-09-09
4630
Participants Needed
1
Research Sites
8 weeks
Total Duration
On this page
Sponsors
U
University of Florida
Lead Sponsor
N
National Cancer Institute (NCI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This research aims to address disparities in HPV-related cancer prevention in rural areas by evaluating the effects of different strategies to increase HPV vaccination rates among 9- to 12-year-olds. The study focuses on improving clinician recommendations, parental motivation, and healthcare access in 11 rural North Central Florida counties. It uses a three-arm cluster randomized design to compare these approaches and understand how patient and clinic factors influence their success. The study involves three groups of clinics receiving layered interventions. All clinics get clinician-targeted recommendation training via a one-hour online session focused on empathetic communication and vaccine promotion. Some clinics also receive parent-targeted motivational aids, including reminder messages and phone-based motivational interviews for parents who do not respond. A subset of clinics receives additional community-targeted healthcare access support, such as transportation help, mobile vaccination clinics, and health insurance navigation. Participants include adolescents aged 8 to 12 who visit participating clinics and have not completed HPV vaccination. Researchers will monitor HPV vaccine initiation over 24 months and track vaccination up-to-date status. Data collection includes clinic records and patient-level information, with statistical models accounting for clinic clustering. The trial lasts at least 24 months, with interventions delivered at the clinic level and ongoing assessments of vaccination uptake and implementation success.
CONDITIONS
Brief Title
ReMARK: Addressing Disparities in Rural HPV-related Cancer Prevention
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adolescents aged 8 to 12 years
- Visited a participating clinic in the past year or during the study
- Have not received both doses of the HPV vaccine
- Receive primary care from providers at a participating clinic
You will not qualify if you...
- Adolescents outside the 8 to 12 years age range
- Providers unwilling to consent to participate
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person or virtual) to confirm eligibility
Duration - Up to 24 months
Participants receive interventions based on their clinic's assigned group, including clinician training, parent-targeted motivational messages and phone-based interviews, and/or healthcare access support such as transportation assistance and mobile vaccination clinics.
Ongoing interventions through clinic visits and outreach; mobile vaccination clinics offered approximately 40 times during the intervention period
Trial Site Locations
Total: 1 location
1
University of Florida
Gainesville, Florida, United States, 32608
Actively Recruiting
Research Team
S
Stephanie Staras, PhD
M
Marta Hansen, MBA
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
3
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