e-SEP Cognition: Effectiveness of a Remediation Program Via a "Serious Game" on the Cognitive Functions of Multiple Sclerosis Patients: Controlled, Randomized, Multicentric Trial

What this Trial Is About

This research aims to evaluate the effectiveness of a cognitive remediation program using a "serious game" to improve information processing speed and episodic memory learning in adults with multiple sclerosis. Cognitive impairment affects 40 to 70% of these patients and leads to slower processing, memory, attention, and executive function difficulties, impacting their daily and work life. The study addresses the need for practical, adaptable remediation strategies, as current training methods show limited lasting benefits and are time-consuming. Participants will be randomly assigned to one of two groups: one receiving classic care recommended by French health authorities plus cognitive remediation through a serious game accessed via an online tablet platform, involving four 20-minute activity sessions per week; the other group will receive classic care alone with non-specific cognitive activity notebooks and similar session instructions. The serious game format targets multiple cognitive functions simultaneously, and the intervention period lasts four months. During the study, participants will undergo neuropsychological evaluations at baseline, 4 months, and 10 months to measure changes in several cognitive tests including verbal learning, visuospatial memory, and processing speed. Researchers will also monitor game play frequency, session length, performance, and various secondary cognitive and quality of life measures. Participants will be followed to assess the durability of cognitive changes and overall impact on autonomy and mood throughout the study period.

Remediation Program Via a "Serious Game" for the Cognitive Functions of Multiple Sclerosis Patients