Actively Recruiting
Remifentanil Effect on Burst Suppression Ratio
Led by University of Chile · Updated on 2025-11-20
20
Participants Needed
2
Research Sites
134 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to determine whether remifentanil has a facilitating effect on the generation of burst suppression by propofol in adult patients (18-60 years) candidates for elective surgery who require remifentanil and American Society of Anesthesiology (ASA) classification I or II. The main question it aims to answer are: • To determine whether remifentanil has a facilitating effect on the generation of burst suppression by propofol. Participants will undergo general anesthesia with remifentanil and propofol sequentially. After loss of consciousness, remifentanil will be adjusted to a medium or high concentration randomly and it will be determined at what concentration of propofol the burst suppressions are generated. Then, the concentrations of propofol that generate burst suppression associated with either a medium or high concentration of remifentanil will be compared.
CONDITIONS
Official Title
Remifentanil Effect on Burst Suppression Ratio
Who Can Participate
Eligibility Criteria
You may qualify if you...
- American Society of Anesthesiology I or II
- Elective surgery of low or intermediate risk
- Age between 18 and 60 years
You will not qualify if you...
- Neurological disease
- Psychiatric disease
- Use of psychoactive drugs or opioids
- Altered basal state of consciousness
- Allergy to propofol
- Body mass index greater than 35 kg/m2
- Pre-existing renal, cardiac and/or hepatic dysfunction
- Patient's refusal to participate
AI-Screening
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Trial Site Locations
Total: 2 locations
1
Centro de Investigación Cínica Avanzada (CICA), Hospital Clinico de la Universidad de Chile
Santiago, RM, Chile, 7690306
Actively Recruiting
2
Hospital Clinico de la Universidad de Chile
Santiago, RM, Chile, 7690306
Actively Recruiting
Research Team
A
Antonello Penna, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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