Influence of Remifentanil Concentrations on Burst Suppression Rate During Propofol Anesthesia in Adults Undergoing Elective Surgery

What this Trial Is About

Researchers are evaluating the effect of remifentanil on the generation of burst suppression by propofol in adult patients aged 18 to 60 years undergoing elective low or intermediate risk surgery. The study focuses on whether different concentrations of remifentanil can influence the propofol concentration needed to produce burst suppression, a specific pattern seen in brain activity during anesthesia. Participants will be classified under American Society of Anesthesiology (ASA) I or II. Participants will receive general anesthesia with sequential administration of remifentanil and propofol. Initially, remifentanil will be given to reach a target concentration, followed by propofol infusion until loss of consciousness (LOC). After LOC and intubation, remifentanil doses will be adjusted randomly to medium or high concentrations while propofol doses vary to observe burst suppression generation. The protocol includes several phases of adjusting drug concentrations and maintaining hemodynamics with support drugs as needed. During the study, participants will have continuous monitoring including frontal EEG to record brain activity, blood pressure, and drug dosage. Loss of consciousness will be checked every 30 seconds during induction. Researchers will measure the propofol concentration at which burst suppression occurs and at LOC, along with blood pressure and doses of medications used to maintain stability. The total study duration per participant covers the anesthesia period with follow-up during surgery as per protocol requirements.

Remifentanil Effect on Burst Suppression Ratio