Actively Recruiting
Remimazolam for Bronchoscopy in High-Risk Patients
Led by First Affiliated Hospital of Zhejiang University · Updated on 2026-02-24
360
Participants Needed
2
Research Sites
42 weeks
Total Duration
On this page
Sponsors
F
First Affiliated Hospital of Zhejiang University
Lead Sponsor
S
Shaoxing People's Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
Bronchoscopy is currently widely used for the diagnosis and treatment of various respiratory diseases. However, the operation of bronchoscopy is irritating, causes a strong stress response, and shares the airway with the patient, making the patient highly susceptible to respiratory and cardiovascular risks. Among these risks, hypoxia is the most common adverse event.Different drug regimens can be selected for anesthesia under deep sedation. The combination of analgesic agents can help reduce coughing during bronchoscopy. Therefore, we employ a combination of sedative and analgesic drugs for painless bronchoscopy procedures. Among sedatives, propofol is the most commonly used. However, due to its disadvantages, such as respiratory and circulatory depression, we have introduced a novel approach combining remimazolam for sedation. The aim is to investigate whether this new regimen, compared to traditional propofol-based sedation, can reduce the incidence of hypoxia, minimize circulatory depression, and lead to faster postoperative awakening and recovery. Additionally, we hope to observe fewer adverse events, such as perioperative nausea and vomiting, excessive secretions, dizziness, and chills.
CONDITIONS
Official Title
Remimazolam for Bronchoscopy in High-Risk Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- ASA Class II to III
- Scheduled for elective painless bronchoscopy
You will not qualify if you...
- Under 18 years of age
- Uncooperative patients (e.g., due to mental illness)
- Chronic use of opioids, benzodiazepine-class hypnotics, or antidepressants
- History of allergy to the anesthetics used
- Anticipated difficult airway
- Body mass index (BMI) less than 18.5 kg/m² or greater than 30 kg/m²
- Preoperative oxygen saturation below 92% while breathing room air
- Any other condition deemed unsuitable by the investigator
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 2 locations
1
The First Affliated Hospital, Zhejiang University School Of Medicine
Hangzhou, Zhejiang, China, 310000
Actively Recruiting
2
Shaoxing City First People's Hospital
Shaoxing, Zhejiang, China, 310000
Not Yet Recruiting
Research Team
Y
Yueying Zheng
CONTACT
Y
Yeke Zhu
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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