Actively Recruiting
Remimazolam for Cataract Surgery
Led by University of California, Los Angeles · Updated on 2025-03-19
120
Participants Needed
1
Research Sites
42 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this study is to assess any post operative cognitive changes following benzodiazepine administration during cataract surgery. The investigators will compare effects of Midazolam vs. Remimazolam on cognition at the time of discharge from the post operative care unit and the next day following surgery. Cognitive changes will be assessed by administration of Montreal Cognitive Assessment (MoCA). Participants will: 1. Complete MoCA testing prior to surgery 2. Randomize in either Midazolam or study drug Remimazolam 3. Complete MoCA testing after surgery at the time of discharge in the post anesthesia care unit and the next day of surgery at the time of post operative surgical visit. 4. Complete Patient Satisfaction Survey at the time of discharge from the Post Anesthesia Care Unit (PACU)
CONDITIONS
Official Title
Remimazolam for Cataract Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patients age > 65 years undergoing first eye cataract surgery under local topical anesthesia at the University of California, Los Angeles (UCLA).
- Both male and female patients
- American Society of Anesthesiologists Class 2, 3, and 4.
You will not qualify if you...
- Patients who are unable to consent for the study
- Patients who are unable to cooperate with the cognitive assessment such as patients with significant visual, auditory, language or other impairment.
- Patients who are unable to understand simple English commands.
- Patients who do not wish to have benzodiazepine medication during surgery
- Patients with a history of severe hypersensitivity reaction to dextran 40 or products containing dextran 40.
- Patients with chronic pain on opiates.
- Patients with a history of drug, alcohol abuse/dependence.
- Patients with BMI > 40.
- Patients with obstructive sleep apnea (moderate to severe).
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Ronald Reagan UCLA Medical Center, Department of Anesthesiology & Perioperative Medicine
Los Angeles, California, United States, 90095
Actively Recruiting
Research Team
Z
Zhuang T Fang, MD
CONTACT
S
Stephanie-Dee Sarovich, BS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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