Actively Recruiting

Early Phase 1
Age: 3Years - 8Years
All Genders
Healthy Volunteers
NCT06489093

Remineralizing Effect of Different Silver-containing Agents on Initial Caries Lesions in Primary Teeth in Children

Led by Plovdiv Medical University · Updated on 2024-07-05

30

Participants Needed

1

Research Sites

43 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

The aim of the present work is to study the effect of the application of Silver diamine fluoride (SDF) and a novel green synthesized Nano-silver fluoride (NSF) on early enamel lesions in primary teeth. Proving their positive effect would be the basis for the development of innovative dental materials and hygienic agents to combat the carious process, which is a critical prerequisite for improving the quality of dental services and reducing dental anxiety and fear.

CONDITIONS

Official Title

Remineralizing Effect of Different Silver-containing Agents on Initial Caries Lesions in Primary Teeth in Children

Who Can Participate

Age: 3Years - 8Years
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Age between 3 and 8 years
  • Signed informed consent from parents and verbal consent from the child
  • Healthy children without diseases or conditions that reduce saliva flow
  • Presence of early enamel carious lesions (white spots) assessed by ICDAS and laser fluorescence criteria
  • No remineralization or topical fluoride treatment on included lesions within 6 months prior to study
  • No history of allergy to the study medications
Not Eligible

You will not qualify if you...

  • Medically compromised or complex patients with diseases reducing saliva or cognitive/behavioral disorders
  • Received remineralizing or topical fluoride therapy on included lesions in the last 6 months
  • History of allergy to the medications used in the study

AI-Screening

AI-Powered Screening

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Trial Site Locations

Total: 1 location

1

Department of Pediatric Dentistry, Faculty of Dental Medicine, Medical University-Plovdiv

Plovdiv, Bulgaria, 4000

Actively Recruiting

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Research Team

A

Antonia Palankalieva, DMD

CONTACT

A

Ani Belcheva, DMD, PhD

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

3

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