Actively Recruiting
ReModeling in ST-elevation myocARrdial Infarction: a Comparison of Left VEntricuLar Functions in Long-term Follow-up Among STEMI Patients: The MARVEL Study
Led by University of Pisa · Updated on 2025-07-17
80
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying patients diagnosed with ST-elevation myocardial infarction (STEMI) who have undergone primary percutaneous coronary intervention (pPCI). The study aims to evaluate changes in left ventricular function and remodeling over the long term by collecting detailed clinical and laboratory data, including inflammatory markers and heart imaging results. This observational study is sponsored by the University of Pisa and focuses on understanding heart changes after STEMI treatment. During the study, extensive tests are performed including transthoracic echocardiograms (TTE) at admission and before discharge, as well as cardiac magnetic resonance (CMR) imaging before discharge to assess heart tissue and damage. Follow-up visits at six months repeat laboratory tests, CMR, and TTE alongside a full clinical evaluation. The study monitors criteria indicating left ventricular remodeling (LVR), such as increases in heart chamber volumes and changes in heart function. Participants will have their heart health closely observed through imaging and lab tests at key time points, including initial hospital admission, before discharge, and six months later. Researchers evaluate heart structure, function, and injury markers to understand remodeling processes after STEMI. The primary outcome is remodeling assessed over 36 months, with ongoing clinical evaluations to track heart function and complications.
CONDITIONS
Brief Title
ReModeling in ST-elevation myocARrdial Infarction: a Comparison of Left VEntricuLar Functions in Long-term Follow-up Among STEMI Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of ST-elevation myocardial infarction (STEMI)
You will not qualify if you...
- Contraindication to cardiac magnetic resonance (CMR) imaging
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Hospital stay duration
Participants undergo comprehensive diagnostic assessments including laboratory tests, electrocardiographic and echocardiographic evaluations, and cardiac magnetic resonance imaging to characterize myocardial tissue before discharge.
1 to 2 visits during hospital stay
Duration - 6 months
Participants are followed up with repeated laboratory tests, cardiac magnetic resonance imaging, transthoracic echocardiograms, and clinical evaluations to assess left ventricular remodeling and heart function.
1 follow-up visit at 6 months
Trial Site Locations
Total: 1 location
1
University of Pisa, Cisanello Hospital
Pisa, Pisa, Italy, 56124
Actively Recruiting
Research Team
M
Mattia Alberti, Dr
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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