Actively Recruiting
REmote COnditioning in Out-of-Hospital Cardiac Arrest
Led by Hospices Civils de Lyon · Updated on 2025-02-12
220
Participants Needed
14
Research Sites
119 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Out-of-Hospital Cardiac Arrest remains a major public health problem, resulting in high mortality largely related to multiple organ failure and poor neurological outcomes due to brain anoxia. The pathophysiology of organ dysfunction after resuscitated out-of-hospital cardiac arrest involves ischemia-reperfusion processes. Remote ischemic conditioning is a therapeutic strategy used to protect organs against the detrimental effects of ischemia-reperfusion injury. The objective of the present trial is to determine whether remote ischemic conditioning performed early after out-of-hospital cardiac arrest can decrease mortality, or multiple organ failure and/or severe neurological failure.
CONDITIONS
Official Title
REmote COnditioning in Out-of-Hospital Cardiac Arrest
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 80 years old
- Out-of-hospital cardiac arrest regardless of initial cardiac rhythm or timing
- Cardiac arrest witnessed or patient seen alive within 30 minutes prior
- Hospitalized in intensive care unit for less than 3 hours
- Informed consent from close relative or patient if possible, or emergency procedure by investigator
You will not qualify if you...
- Traumatic cardiac arrest
- Patient on extracorporeal circulatory assistance
- Cardiac arrest where resuscitation continuation is unjustified (unavoidable death, terminal disease stage)
- Contraindications to using brachial cuff on both arms (e.g., arteriovenous fistula, lymphoedema, severe peripheral vascular disease, unstable humeral fracture, continuous infusion in upper limb vein of essential drug, radial arterial catheter)
- Pregnant, parturient, or breastfeeding women
- Patients deprived of liberty by judicial or administrative decision
- Patients under legal protection (guardianship, curatorship)
- Patient not affiliated with social security or similar scheme
- Previous inclusion in this study
- Participation in other interventional research that could interfere or has an ongoing exclusion period
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 14 locations
1
Hôpital Louis Pradel
Bron, France, 69500
Not Yet Recruiting
2
Hôpital Gabriel Montpied, CHU de Clermont Ferrand
Clermont-Ferrand, France, 63000
Not Yet Recruiting
3
Centre Jean Perrin, Clermont-Ferrand
Clermont-Ferrand, France, 69300
Not Yet Recruiting
4
Hôpital F Mitterrand, CHU de Dijon
Dijon, France, 21079
Not Yet Recruiting
5
Hôpital Albert Michallon, CHU de Grenoble
La Tronche, France, 38700
Not Yet Recruiting
6
Hôpital Edouard Herriot
Lyon, France, 69003
Actively Recruiting
7
Hôpital Saint-Joseph Saint-Luc
Lyon, France, 69007
Actively Recruiting
8
Hôpital de la Timone, CHU de Marseille
Marseille, France, 13385
Actively Recruiting
9
Hôpital lapeyronie, CHU de Montpellier
Montpellier, France, 34295
Actively Recruiting
10
Hôpital Universitaire Carémeau
Nîmes, France, 30029
Not Yet Recruiting
11
Hôpital Lariboisière, APHP, Réanimation Médicale et Toxicologique
Paris, France, 75010
Not Yet Recruiting
12
Hôpital Lyon-Sud
Pierre-Bénite, France, 69310
Actively Recruiting
13
Hôpital Nord, CHU de St Etienne
Saint-Priest-en-Jarez, France, 42270
Actively Recruiting
14
Hôpital Nord-Ouest
Villefranche-sur-Saône, France, 69655
Actively Recruiting
Research Team
M
Marie-Line Harlay
CONTACT
N
Naoual EL JONHY
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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