Actively Recruiting
Remote Ischemic Conditioning in Out-of-Hospital Cardiac Arrest The RECO-OHCA Study
Led by Hospices Civils de Lyon · Updated on 2025-02-12
220
Participants Needed
14
Research Sites
14 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Out-of-hospital cardiac arrest is a serious public health issue with high death rates caused mainly by multiple organ failure and severe brain damage due to lack of oxygen. Researchers are studying whether remote ischemic conditioning, a treatment that protects organs from injury caused by blood flow returning after a stoppage, can reduce death rates or severe organ and brain damage after such cardiac arrests. The study compares two groups: one group receives remote ischemic conditioning, which involves inflating a cuff on the arm to temporarily stop blood flow for 5 minutes followed by 5 minutes of release, repeated four times and repeated again at 12 and 24 hours after inclusion. The other group has a cuff placed on the arm without any inflation or deflation. This method aims to protect organs by conditioning them against injury from restored blood flow. Participants will be monitored closely in the intensive care unit, with assessments including death rates, organ failure, and severe neurological damage measured 72 hours after hospital admission. Researchers will also track organ function scores, brain injury markers, and survival up to 90 days. The total participation period covers the early hospital phase and follow-up to day 90 to evaluate outcomes and safety.
CONDITIONS
Brief Title
REmote COnditioning in Out-of-Hospital Cardiac Arrest
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 80 years old
- Out-of-hospital cardiac arrest, regardless of heart rhythm or duration of no blood flow
- Presence of a witness to the cardiac arrest or seen alive within 30 minutes before arrest
- Hospitalization in intensive care for less than 3 hours
- Informed consent obtained from a close relative, the patient if possible, or emergency procedure used by investigator
You will not qualify if you...
- Traumatic cardiac arrest
- Use of extracorporeal circulatory assistance
- Cardiac arrest cases where resuscitation is deemed unjustified
- Contraindications to using a brachial cuff on both arms (e.g., arteriovenous fistula, severe arm injury, lymphoedema, unstable fracture, essential drug infusion in arm, arterial catheter)
- Pregnant, parturient, or breastfeeding women
- Patients deprived of liberty by legal decision
- Patients under legal protection (guardianship or curatorship)
- Not affiliated with a social security scheme
- Previous participation in this study
- Participation in other interventional research that may interfere with this study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
screening and enrollment visit
Duration - 24 hours
Participants receive remote ischemic conditioning using a brachial cuff on one arm. The intervention consists of four cycles of 5-minute cuff inflation followed by 5-minute deflation, started as soon as possible after inclusion and repeated at 12 and 24 hours after inclusion. Participants in the control group have the cuff positioned without inflation or deflation.
1 to 3 visits within 24 hours
Duration - Up to 90 days
Participants are monitored for clinical outcomes including organ failure and neurological status up to 72 hours after hospital admission, with additional assessments until Day 90 for long-term outcomes.
Multiple visits including assessments at 24, 48, and 72 hours, and Day 90
Trial Site Locations
Total: 14 locations
1
Hôpital Louis Pradel
Bron, France, 69500
Not Yet Recruiting
2
Hôpital Gabriel Montpied, CHU de Clermont Ferrand
Clermont-Ferrand, France, 63000
Not Yet Recruiting
3
Centre Jean Perrin, Clermont-Ferrand
Clermont-Ferrand, France, 69300
Not Yet Recruiting
4
Hôpital F Mitterrand, CHU de Dijon
Dijon, France, 21079
Not Yet Recruiting
5
Hôpital Albert Michallon, CHU de Grenoble
La Tronche, France, 38700
Not Yet Recruiting
6
Hôpital Edouard Herriot
Lyon, France, 69003
Actively Recruiting
7
Hôpital Saint-Joseph Saint-Luc
Lyon, France, 69007
Actively Recruiting
8
Hôpital de la Timone, CHU de Marseille
Marseille, France, 13385
Actively Recruiting
9
Hôpital lapeyronie, CHU de Montpellier
Montpellier, France, 34295
Actively Recruiting
10
Hôpital Universitaire Carémeau
Nîmes, France, 30029
Not Yet Recruiting
11
Hôpital Lariboisière, APHP, Réanimation Médicale et Toxicologique
Paris, France, 75010
Not Yet Recruiting
12
Hôpital Lyon-Sud
Pierre-Bénite, France, 69310
Actively Recruiting
13
Hôpital Nord, CHU de St Etienne
Saint-Priest-en-Jarez, France, 42270
Actively Recruiting
14
Hôpital Nord-Ouest
Villefranche-sur-Saône, France, 69655
Actively Recruiting
Research Team
M
Marie-Line Harlay
N
Naoual EL JONHY
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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