Actively Recruiting
Remote Ischaemic Conditioning in the Older Person and Effects on Dynamic Cerebral Autoregulation
Led by University of Nottingham · Updated on 2025-09-18
45
Participants Needed
1
Research Sites
109 weeks
Total Duration
On this page
Sponsors
U
University of Nottingham
Lead Sponsor
U
University of Leicester
Collaborating Sponsor
AI-Summary
What this Trial Is About
Remote Ischaemic Conditioning (RIC) is the process of inducing short periods of ischaemia in a limb with the aim of improving vascular health systemically. Recent findings have demonsatrated efficacy in a variety of clinical settings. However, the ideal protocol of RIC \[dose\] is unknown. Dynamic Cerebral Autoregulation (dCA) has been shown to increase in response to RIC. The goal of this trial is to study whether an increase in RIC protocol intensity results in a larger effect on biomarkers of vascular health such as dCA. Participants shall: Receive RIC daily, RIC thrice weekly or sham RIC thrice weekly for 6 weeks Visit the School of Medicine at baseline and at 6 weeks for measurement of biomarkers of vascular health including blood pressure, indices od dCA and blood plasma samples
CONDITIONS
Official Title
Remote Ischaemic Conditioning in the Older Person and Effects on Dynamic Cerebral Autoregulation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Willing and able to give informed consent for participation in the study
- Aged between 65 and 85 years
- Able to perform Remote Ischaemic Conditioning independently at home
You will not qualify if you...
- Active cardiovascular or cerebrovascular disease within the last 12 months
- Atrial fibrillation or other significant arrhythmias
- Peripheral Vascular Disease
- Haemostatic disorders
- Soft tissue injury or fracture to the upper limb
- Pregnant or breastfeeding
- History or current psychiatric illness
- History or current neurological condition such as epilepsy
- Inability to identify temporal window for transcranial doppler ultrasound at screening
- Any condition deemed by the study clinician to exclude participation
- Participation in a research study in the last 3 months involving invasive procedures or inconvenience allowance
AI-Screening
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Trial Site Locations
Total: 1 location
1
School of Medicine, University of Nottingham, Royal Derby Hospital Centre
Derby, Derbyshire, United Kingdom, DE22 3DT
Actively Recruiting
Research Team
H
Harry Keevil, MB BChir
CONTACT
T
Tim England, MBChB PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
3
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