Actively Recruiting
Remote Ischemic Conditioning for Acute Ischemic Stroke Treated With Mechanical Thrombectomy（RECAST-MT）
Led by Capital Medical University · Updated on 2025-12-10
2105
Participants Needed
56
Research Sites
123 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
For patients with acute ischemic stroke caused by large vessel occlusion, endovascular thrombectomy has been demonstrated to be the most effective therapy, as approximately 90% of the occluded vessels can be recanalized. However, less than 50% of patients could achieve functional independence, and over 15% died 90 days after stroke. Although the mismatch of successful recanalization with poor prognosis can be attributed to many factors, the infarct core formed during thrombectomy and reperfusion injury after thrombectomy may be among the most important and effective neuroprotective strategies urgently needed. Remote ischemic conditioning (RIC) is a noninvasive strategy in which one or more cycles of brief and transient limb ischemia confer protection against prolonged and severe ischemia in distant organs. In the transient focal cerebral ischemia-reperfusion model, the application of remote ischemic conditioning before reperfusion or both before and after reperfusion reduces reperfusion injuries and the final infarct size. Because patients with acute ischemic stroke who are treated with endovascular thrombectomy can achieve a high rate of recanalization after focal ischemia, this patient population is akin to the model of transient focal cerebral ischemia-reperfusion. Furthermore, a pilot study has determined the safety and feasibility of remote ischemic conditioning in patients undergoing endovascular thrombectomy. However, whether remote ischemic conditioning could provide clinical benefits to patients with acute ischemic stroke who are treated with endovascular thrombectomy urgently needs investigations. This study aims to investigate the safety and efficacy of remote ischemic conditioning in improving functional outcomes of patients with acute ischemic stroke treated with endovascular thrombectomy and explore the effect of treatment duration on the treatment outcome of remote ischemic conditioning.
CONDITIONS
Official Title
Remote Ischemic Conditioning for Acute Ischemic Stroke Treated With Mechanical Thrombectomy（RECAST-MT）
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Acute ischemic stroke due to large vessel blockage in the anterior brain circulation
- Large vessel blockage confirmed by CT or MR angiography, with planned mechanical thrombectomy within 24 hours
- National Institutes of Health Stroke Scale (NIHSS) score of 6 points or higher at baseline
- Signed informed consent by patient or family members
You will not qualify if you...
- Stroke involving multiple brain blood vessel areas (both anterior and posterior circulation)
- No detectable femoral artery pulse, very difficult vascular access, or very twisted large vessels preventing timely treatment
- Uncontrolled high blood pressure (systolic ≥180 mmHg or diastolic ≥100 mmHg)
- Coma or lethargy with consciousness score of 2 or higher on NIHSS
- Unable to obtain accurate baseline NIHSS score
- Pre-stroke disability with modified Rankin Scale score greater than 1
- Baseline ASPECTS score of 5 or less
- Bleeding tendency, clotting factor deficiencies, or anticoagulant therapy with INR over 3.0
- Very low or very high blood glucose levels (<2.7 mmol/L or >22.2 mmol/L)
- Platelet count below 30 x 10^9/L
- Severe kidney failure requiring dialysis or creatinine clearance below 30 mL/min
- Intracranial bleeding seen on CT or MRI
- Brain shift or large mass effect on imaging
- History or signs of brain tumors, arteriovenous malformations, or arterial dissection
- Head injury within the last 3 months
- Life-threatening allergy to contrast agents or metals used in devices
- Pregnant or breastfeeding women
- Life expectancy less than 6 months or unable to be evaluated within 3 months
- Limb deformity or injury affecting treatment
- Participation in other clinical trials
- Other conditions judged unsuitable by investigators
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 56 locations
1
Suzhou Municipal Hospital of Anhui Province
Suzhou, Anhui, China, 234000
Actively Recruiting
2
Taihe County People's Hospital
Taihe Chengguanzhen, Anhui, China, 236600
Actively Recruiting
3
Tongling People's Hospital
Tongling, Anhui, China
Actively Recruiting
4
Beijing Luhe Hospital affiliated to Capital Medical University
Beijing, Beijing Municipality, China, 100000
Actively Recruiting
5
Beijing Fangshan District First Hospital
Beijing, Beijing Municipality, China, 100010
Actively Recruiting
6
Fujian Provincial Hospital
Fuzhou, Fujian, China, 350028
Not Yet Recruiting
7
Zhangzhou Municipal Hospital of Fujian Province
Zhangzhou, Fujian, China, 363000
Actively Recruiting
8
Shenzhen Second People's Hospital
Shenzhen, Guangdong, China, 518000
Not Yet Recruiting
9
South China Hospital Affiliated to Shenzhen University
Shenzhen, Guangdong, China, 518000
Actively Recruiting
10
The Second Nanning People's Hospital
Nanning, Guangxi, China, 530000
Actively Recruiting
11
Cangzhou Central Hospital
Cangzhou, Hebei, China, 061000
Actively Recruiting
12
Army Medical University Noncommissioned Officer School Affiliated Hospital
Shijiazhuang, Hebei, China, 050047
Actively Recruiting
13
Hebei General Hospital
Shijiazhuang, Hebei, China, 455001
Not Yet Recruiting
14
The Hongda Hospital of Jiamusi University
Jiamusi, Heilongjiang, China, 154000
Actively Recruiting
15
Xunxian People's Hospital
Hebi, Henan, China, 456250
Actively Recruiting
16
Jiaozuo Coal Industry Group Co., Ltd. Central Hospital
Jiaozuo, Henan, China, 454000
Actively Recruiting
17
Luoyang Yanshi People's Hospital
Luoyang, Henan, China, 471000
Actively Recruiting
18
Nanyang Central Hospital
Nanyang, Henan, China, 473000
Actively Recruiting
19
Henan Province People's Hospital
Zhengzhou, Henan, China, 450000
Not Yet Recruiting
20
Xihua county people's hospital
Zhoukou, Henan, China, 466600
Actively Recruiting
21
Huanggang Central hospital
Huanggang, Hubei, China, 438000
Actively Recruiting
22
Huangshi central hospital
Huangshi, Hubei, China, 435000
Actively Recruiting
23
Jingmen Central hospital
Jingmen, Hubei, China, 448000
Actively Recruiting
24
Jingmen People's Hospital
Jingmen, Hubei, China, 448000
Actively Recruiting
25
First People's Hospital of Tianmen
Tianmen, Hubei, China, 430000
Suspended
26
Zhongnan Hospital of Wuhan University
Wuhan, Hubei, China, 430000
Actively Recruiting
27
The Third People's Hospital of Hubei Province
Wuhan, Hubei, China, 430033
Not Yet Recruiting
28
Yichang Central People's Hospital
Yichang, Hubei, China, 443000
Actively Recruiting
29
the First People's Hospital of Changde
Changde, Hunan, China, 415000
Actively Recruiting
30
The Third Xiangya Hospital of Central South University
Changsha, Hunan, China, 410000
Actively Recruiting
31
the First People's Hospital of Chenzhou
Chenzhou, Hunan, China, 423000
Not Yet Recruiting
32
The Central Hospital of Xiangtan
Xiangtan, Hunan, China, 411100
Not Yet Recruiting
33
Inner Mongolia Autonomous Region People's Hospital
Hohhot, Inner Mongolia, China, 010000
Not Yet Recruiting
34
The Fourth Affiliated Hospital of Soochow University
Suzhou, Jiangsu, China, 215000
Actively Recruiting
35
The First Affiliated Hospital of Soochow University
Suzhou, Jiangsu, China, 215006
Actively Recruiting
36
Anshan Changda Hospital
Anshan, Liaoning, China, Anshan
Actively Recruiting
37
Dalian Central Hospital
Dalian, Liaoning, China, 116000
Not Yet Recruiting
38
The First Affiliated Hospital of Dalian Medical University
Dalian, Liaoning, China, 116000
Actively Recruiting
39
Shengli Oilfield Central Hospital
Dongying, Shandong, China, 257000
Actively Recruiting
40
Jinan Third People's Hospital
Jinan, Shandong, China, 250000
Actively Recruiting
41
Liaocheng People's Hospital
Liaocheng, Shandong, China, 252000
Actively Recruiting
42
Liaocheng Third People's Hospital
Liaocheng, Shandong, China, 252000
Actively Recruiting
43
The People's Hospital of Gaotang
Liaocheng, Shandong, China, 252800
Actively Recruiting
44
Feixian People's Hospital
Linyi, Shandong, China, 273400
Suspended
45
Yeda Hospital
Yantai, Shandong, China
Actively Recruiting
46
Mianyang third people's hospital
Mianyang, Sichuan, China, 621000
Actively Recruiting
47
Ya 'an People's Hospital
Ya'an, Sichuan, China, 625000
Actively Recruiting
48
The Second Affiliated Hospital of Wenzhou Medical University
Wenzhou, Zhejiang, China, 325000
Actively Recruiting
49
Yueqing People's Hospital
Yueqing, Zhejiang, China, 325600
Actively Recruiting
50
Beijing Chao-Yang Hospital
Beijing, China, 100020
Actively Recruiting
51
Aerospace Central Hospital
Beijing, China, 100049
Actively Recruiting
52
Xuanwu Hospital, Capital Medical University
Beijing, China, 100053
Actively Recruiting
53
Beijing Fengtai You'anmen Hospital
Beijing, China, 100071
Actively Recruiting
54
Beijing Red Cross Emergency Medical Center
Beijing, China, 100085
Actively Recruiting
55
Beijing Daxing District People's Hospital
Beijing, China, 102600
Actively Recruiting
56
Chongqing University Fuling Hospital
Chongqing, China, 408000
Not Yet Recruiting
Research Team
X
Xunming Ji, MD, PhD
CONTACT
S
Sijie Li, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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