Actively Recruiting
Remote Ischemic Conditioning for Acute Moderate Ischemic Stroke Due to Large Artery Atherosclerosis
Led by First Affiliated Hospital Xi'an Jiaotong University · Updated on 2025-08-14
1150
Participants Needed
1
Research Sites
107 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Large Artery Atherosclerosis is one of the most prevalent causes of stroke worldwide and is associated with a high risk of disability and recurrent strokes. Remote Ischemic Conditioning (RIC) is a promising therapy, and it has been recommended for further investigation in patients with acute ischemic stroke resulting from large artery atherosclerosis. The primary objective of this study is to assess the efficacy of RIC in patients suffering from acute moderate ischemic stroke due to large artery atherosclerosis.
CONDITIONS
Official Title
Remote Ischemic Conditioning for Acute Moderate Ischemic Stroke Due to Large Artery Atherosclerosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female aged 18 to 85 years old
- Randomization within 48 hours after stroke symptom onset
- Ischemic stroke confirmed by MRI diffusion-weighted imaging
- NIHSS score 6-16, or 4-5 with disabling deficits at randomization
- Large vessel 50%-99% stenosis or occlusion confirmed by MRA, CTA, or DSA in specific brain arteries
- Pre-stroke modified Rankin Scale score of 0-1
- Signed Informed Consent obtained
You will not qualify if you...
- Thrombolysis or endovascular therapy performed or planned for current stroke
- Suspected or confirmed cardioembolic stroke source, including atrial fibrillation and others
- Multiple cerebral infarctions in more than one vascular territory
- Uncommon causes of cerebrovascular disorders like arterial dissection, Moyamoya disease, vasculitis, and others
- Subclavian artery stenosis ≥ 50% or subclavian steal syndrome
- Refractory hypertension with persistently high blood pressure after treatment
- Intracranial tumors (except small meningioma), abscess, or arteriovenous malformation
- Bleeding risk including low platelets, recent heparin use with prolonged APTT, or high INR on warfarin
- Undergoing dialysis or severe kidney insufficiency
- Respiratory failure
- Contraindications for Remote Ischemic Conditioning such as severe injury or vascular problems in upper limbs
- Severe comorbid conditions with life expectancy less than 6 months
- Current participation in another investigational trial
- Pregnancy
- Considered unsuitable for the study by researchers
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
The First Affiliated Hospital of Xi'an Jiaotong University
Xi'an, Shaanxi, China, 710061
Actively Recruiting
Research Team
S
Suhang Shang
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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