Study of Remote Ischemic Conditioning to Improve Recovery After Aneurysmal Subarachnoid Hemorrhage

What this Trial Is About

Researchers are evaluating the effect of remote ischemic conditioning RIC, a therapy using repeated short cycles of limb blood flow restriction and reperfusion, in patients with aneurysmal subarachnoid hemorrhage aSAH. This serious type of stroke often leads to complications such as delayed cerebral ischemia DCI, which occurs in 30% of patients and causes significant disability or death. The study aims to determine if RIC can improve long-term functional independence compared to a sham treatment. Participants are randomly assigned to one of two groups the RIC group receives five cycles of 5-minute blood flow restriction followed by 5 minutes of reperfusion on the leg daily for up to 14 days, starting within 24 to 72 hours after hemorrhage and aneurysm treatment. The sham group undergoes a similar procedure with cuff inflation only to 50 mm Hg, which does not block blood flow, repeated daily for the same duration. Both treatments are delivered using an automatic tourniquet device. During the study, participants will be assessed for clinical outcomes using the modified Rankin scale at 14 days and 6 months, brain imaging to measure infarct growth, and the occurrence of delayed cerebral ischemia. Researchers will also monitor mortality at 3 and 12 months and angiographic vasospasm. The study includes safety monitoring and will last several months to capture long-term recovery data.

Remote Ischemic Conditioning in Aneurysmal SAH