Study of Remote Ischemic Conditioning Plus Carotid Artery Stenting to Improve Outcomes in Patients with Symptomatic Carotid Artery Stenosis

What this Trial Is About

Researchers are evaluating the use of remote ischemic conditioning RIC combined with carotid artery stenting CAS in patients who have symptomatic moderate to severe carotid artery stenosis. This study aims to find out if chronic RIC can lower the risk of major vascular events and improve clinical outcomes in high-risk patients after receiving CAS. The trial is a prospective, randomized controlled study designed to assess long-term benefits and safety of RIC in this group. The treatment involves a device-based RIC protocol where a cuff is inflated on both upper arms to 200 mmHg for 5 minutes, followed by 5 minutes of deflation, repeated for five cycles. This is done once or twice daily, starting three days before CAS and continuing for 12 months after the procedure. Participants are randomly assigned to either the RIC group receiving this treatment or a control group with no RIC treatment. Participants will be involved in the study for at least 12 months post-randomization, during which researchers will track the time until major vascular events occur. Various assessments include monitoring for stroke, transient ischemic attacks, myocardial infarction, in-stent restenosis, and brain imaging to detect new infarcts or tissue changes. Safety evaluations will occur shortly after the stenting procedure, with follow-up visits assessing neurological status and overall mortality. The study also measures functional outcomes using the modified Rankin Scale over the course of the year.

Remote Ischemic Conditioning Plus Stenting for Symptomatic Carotid Artery Stenosis