Actively Recruiting
Remote Ischemic Conditioning and Spinal Reflex Modulation in Children With Cerebral Palsy
Led by East Carolina University · Updated on 2026-03-24
16
Participants Needed
1
Research Sites
74 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Remote ischemic conditioning (RIC) is a clinically feasible intervention involving brief, sublethal periods of ischemia followed by reperfusion that has been shown to enhance motor performance, strength, and balance when combined with training in healthy adults and individuals with neurological conditions. Although RIC is thought to influence neuroplasticity through neural, metabolic, and humoral pathways, its effects on spinal-level mechanisms remain poorly understood. Emerging evidence indicates that neuroplastic adaptations occur not only at the cortical level but also within the spinal cord. Moreover, altered spinal reflex excitability is associated with spasticity, balance impairments, and functional limitations in children with cerebral palsy (CP), yet the role of spinal reflex modulations in response to RIC and balance training remains under expplored in this population. Therefore, this study aims to investigate the effects of RIC combined with balance training on spinal reflex modulation in children with CP.
CONDITIONS
Official Title
Remote Ischemic Conditioning and Spinal Reflex Modulation in Children With Cerebral Palsy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Children diagnosed with cerebral palsy between 8 and 17 years old
- Gross motor function classification system levels I to III
- Enrolled in mainstream school with sufficient cognition to follow study instructions
You will not qualify if you...
- Other developmental disabilities such as autism or developmental coordination disorders
- Significant cognitive deficits affecting understanding or communication
- Balance disorders including vestibular disorders or posterior fossa tumor
- Known cardiorespiratory dysfunctions
- Sickle cell disease
- Receiving other adjunct therapies like transcranial magnetic stimulation or vagal nerve stimulation
- Lower extremity condition, injury, or surgery within the last three months
- Pregnancy
AI-Screening
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Trial Site Locations
Total: 1 location
1
East Carolina University
Greenville, North Carolina, United States, 27834
Actively Recruiting
Research Team
S
Swati M Surkar, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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